Immunological test procedure

Details Immunological test procedure Immunological test procedure

1975-12-08

1978-06-20

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424 12, A23T 106, C07G 700

Patent

active

040961389

ABSTRACT:
A method is described for conducting immunological tests in which a hapten or antigen is coupled to a soluble macromolecule of natural origin which complex is then aggregated into a particulate suspension which can then be used in an agglutination or indirect agglutination test procedure for detecting antigens or haptens similar in special configuration to that coupled to the macromolecule or detecting antibodies specific for such haptens or antigens. The aggregation for the protein can be affected initially with subsequent coupling of the hapten or antigen to it, or aggregation can be effected after hapten or antigen coupling to the macromolecule.
The test procedure utilizing such aggregate macromolecule-hapten or macromolecule-antigen complexes may be achieved in indirect agglutination test in well trays or by the augmentation with antibody against the species of animal from which antibody against the hapten or antigen has been prepared, effect a direct agglutination on a slide.

REFERENCES:
patent: 2372066 (1945-03-01), Fell
patent: 3553310 (1971-01-01), Csizmas et al.
patent: 3690834 (1972-09-01), Goldstein et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3940475 (1976-02-01), Gross
patent: 3975342 (1976-08-01), Gross

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