Immunological preparations

Details Immunological preparations Immunological preparations

1977-08-22

1978-09-26

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3912, A61K 3918

Patent

active

041171136

ABSTRACT:
Immunological preparations are described in which liposomes having negative charge are used as adjuvants for the purposes of human and veterinary vaccines containing viral antigens. The formulation of influenza antigen in liposomes formed with egg lecithin is described and the adjuvant effect demonstrated.

REFERENCES:
patent: 4053585 (1977-10-01), Allison et al.
Haywood, A. M. J. Mol. Biol., 1974 83(4): 427-436 "Characteristics of Sendai Virus Receptors in a Model Membrane".
Haywood, A. M. J. Mol. Biol. 1974 87(3): 625-628 "Fusion of Sendai Viruses with Model Membranes".
Gregoriadis, G. et al., F.E.B.S. Letters 1974 45(1): 71-74 "Entrapment of Proteins in Liposomes Prevents Allergic Reactions in Preimmunized Mice".
Mooney, J. J. et al., J. Virol. 1975 15(2): 225-231 "Interaction of Sindbis Virus with Liposomal Model Membranes".
Heath, T. D. et al., Biochem. Soc. Trans. 1976 4(1): 129-133 "The Adjuvant Properties of Liposomes".
Wilson, T. et al., Proc. Natl. Acad. Sci. U.S.A. 74(8): 3471-3475 "Biological Properties of Poliovirus Encapsulated in Lipid Vesicles" (1977).

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