Immunological preparations

Details Immunological preparations Immunological preparations

1975-06-25

1977-10-11

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 89, 424199, A61K 3900, A61K 3902, A61K 3912, A61K 3918

Patent

active

040535851

ABSTRACT:
Immunological preparations are described in which liposomes having a negative charge are used as adjuvants for the purposes of human and veterinary vaccines containing viral or bacterial antigens. The formulation of influenza antigen, and diphtheria and tetanus toxoid antigens in liposomes formed with egg lecithin is described and the adjuvant effect demonstrated.

REFERENCES:
patent: 3317393 (1967-05-01), Chanock et al.
patent: 3376199 (1968-04-01), Colbs et al.
patent: 3384544 (1968-05-01), Walton et al.
patent: 3492399 (1970-01-01), Prigal
patent: 3579633 (1971-05-01), Thomson
patent: 3594476 (1971-07-01), Merrill
patent: 3608066 (1971-09-01), Illartein
patent: 3715432 (1973-02-01), Merrill
patent: 3752886 (1973-08-01), Munder et al.
patent: 3755557 (1973-08-01), Jacobs
patent: 3887698 (1975-06-01), McConnell et al.
Chem. Abst. 79 No. 45830T of Ger. Offen. 2,249,552 May 30, 1973.
Chem. Abst. 81 No. 82398V of S. Afr. 73 01,850 Nov. 14, 1973.
Chem. Abst. 83 No. 33053M of Neth. Appl. 74 04,133 Sept. 25, 1974.
Chem. Abst. 83 No. 33033E of Fr. Demande 2,221,122 Oct. 11, 1974.
Chem. Abst. 83 No. 229V of Juliano et al., Biochem. BioPhys. Res. Commun. 1975 63(3), pp. 651-658, Effect of Particle Size and Charge on the Clearance Rates of Liposomes and Liposome Encapsulated Drugs.
7,301,850 11001973 ZA
Mellanby et al. (1968) J. Gen. Microbiol. 54: pp. 161-168 "Ganglioside as a Prophylactic Agent in Experimental Tetanus in Mice".
Sessa et al. J. Biol. Chem. (1970) 245(13): pp. 3295-3301 "Incorporation of Lysozyme into Liposomes."
Kaplan (1972) Biochem. Biophys. Acta 290: pp. 339-347 "Anion Diffusion across Artificial Lipid Membranes."
Papahadjopoulos et al. Biochem. Biophys. ACTA. 352:10-28 May 30, 1974 "Membrane Fusion and Molecular Segregation in Phospholipid Vesicles."
Juliano et al. Biochem. Biophys. Res. Comm. 63(3) (1975) pp. 651-658 "The Effect of Particle Size and Charge on the Clearance Rates of Liposomes and Liposome Encapsulated Drugs."

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