Immunological preparation for concurrent specific binding to spa

Details Immunological preparation for concurrent specific binding to spa Immunological preparation for concurrent specific binding to spa

1997-03-03

2000-02-08

Saunders, David

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds eukaryotic cell or component thereof or substance...

424 149, 424 91, 4241821, 4241781, 4241331, 4241741, 5303873, 5303882, 5303891, 5303913, 5303917, A61K 39395, A61K 4900, C12P 2108, C07K 1618

Patent

active

060225416

ABSTRACT:
The present invention provides an immunological preparation comprising not less than two types of conjugate molecules in admixture for concurrent specific binding to a spatially exposed region of vascular permeability factor (VPF) bound in-vivo to a tumor-associated blood vessel. Each conjugate molecule type comprises at least a binding portion of an antibody specific for an epitope present within a spatially exposed region of bound VPF; and an effector moiety covalently bound to the specific binding portion. The immunological preparation has wide uses and applications including analytical studies, in-vivo diagnostic testing, and in-vivo therapeutic treatments.

REFERENCES:
patent: 4514505 (1985-04-01), Canfield et al.
patent: 5659013 (1997-08-01), Senger et al.
Asano, M et al. Hybridoma. 14(5):475-480, Oct. 1995.
De Santes, K et al. Cancer Research. 52:1916-1923, Apr. 1, 1992.

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