Immunological methods for the detection of the human type IV col

Details Immunological methods for the detection of the human type IV col Immunological methods for the detection of the human type IV col

1990-12-20

1994-10-11

Nucker, Christine M.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436503, 436543, 436547, 5303871, 5303879, 5303891, 5303911, 5303913, 435 71, G01N 3353, G01N 33569, C12Q 100, C07K 1500

Patent

active

053546903

ABSTRACT:
The present invention provides for a method for preparing antibodies that specifically detect the type IV collagen .alpha.5 chain that is defective in various basement membrane disorders such as in X chromosome-linked Alport's syndrome. The invention further provides for the use of such antibodies to detect the .alpha.5(IV) collagen chain in solutions and other human tissue specimens using immunological methods comprised of antibodies specific for said protein. Along this line, the invention relates to the use of the specific antibodies to examine the presence or absence of the .alpha.5(IV) collagen chain in the tissues, e.g. skin or kidneys, etc. of patients with renal failure, possibly due to Alport's syndrome.

REFERENCES:
patent: 4554101 (1985-11-01), Hopp
patent: 5082926 (1992-01-01), Chelberg et al.
Identification of a distinct type IV collagen & chain with restricted kidney distribution and assignment of its gene to the locus of x-chromosome-linked Al port syndrome: Proc Natl. Acad Sci. vol. 87, pp. 1606-1610, Feb. 1990 Hostikka et al.
The Complete Primary Structure of the .alpha.2 Chain of Human Type IV Collagen and Comparison with the 21(IV) Chain, Hostikka & Trycavason J. Biol Chem., 263, No. 36 pp. 19488-19493, 1988.

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