Immunological method for the determination of free substances ha

Details Immunological method for the determination of free substances ha Immunological method for the determination of free substances ha

1988-08-15

1992-01-07

Maples, John S.

Chemistry: analytical and immunological testing

Thyroid hormone tests

436527, 436531, 436817, G01N 33552, G01N 33545, G01N 3378

Patent

active

H00010189

ABSTRACT:
1. Immunological method for the determination of free substances having hapten properties.
2.1. Immunological methods for the determination of free substances having hapten properties, especially of free thyroid hormones, are based on various determination principles, all of which either have disadvantages from the practical viewpoint or, by reason of the basic principle of the method, provide limited information in marginal cases. The new method is intended to simplify and improve the routine clinical determination of free substances, because of the avoidance of sources of error associated with known methods, while having a procedure which is straightforward for practical use.
2.2. The method for the determination of free substances which has hitherto existed only as a theoretical model, in which a labelled antibody and an excess of the substance which is to be determined and is in immobilized form are added to the sample to be investigated, becomes a reilable method for the determination of free substances when, in contrast to previous assumptions, the affinity of the immobilized substance with respect to the labelled antibody is less than 50% of the affinity of this antibody with respect to the substance which is to be determined in the sample.
2.3. Routine clinical determination of free substances, especially thyroid hormones.

REFERENCES:
patent: 4410633 (1983-10-01), Hertl et al.
patent: 4434236 (1984-02-01), Freytag

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