Textiles: fiber preparation
Patent
1972-06-09
1976-01-13
Naff, David M.
Textiles: fiber preparation
195 99, 424 2, 424 12, G01N 3114
Patent
active
039322211
ABSTRACT:
This invention relates to a process, to a diagnostic agent employed therein and to the use thereof, for the organ-specific and/or disease-specific diagnosis of the isozyme pattern of an enzyme occurring in multiple molecular configurations in a sample of human body fluids, tissue extracts or excretions, wherein total enzyme activity is quantitatively measured employing a conventional agent for the determination of enzyme activity, which comprises selectively forming an isozyme-antibody complex of a diagnostically relevant isozyme of the isozyme pattern of the enzyme present in the sample by employing a homologous antisera against the same human isozyme in a form free from the immunological activity of other isozymes of the same enzyme, separating the thus-formed isozyme-antibody complex substantially quantitatively, and measuring residual enzyme activity of the enzyme present in the sample.
REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
McGeachin et al., Serological Differentiation of Amylase Isozymes. Ann. N.Y. Acad. Sci. Vol. 94 1961 (pp. 996-1003).
Nisselbaum, et al., Reactions of Human Tissue Lactic Dehydrogenases with Antisera to Human Heart and Liver Lactic Dehydrogenases. J. of Biol. Chem. Vol. 236 No. 2 1961 (pp. 401-404).
Wilkinson, J. H., Clinical Applications of Isoenzymes, Clinical Chemistry. Vol. 16, No. 9, 1970 (pp. 733-739).
Markert, et al., Immunochemical Properties of Lactate Dehydrogenase Isozymes, Annals New York Academy of Sciences, 103, 1963 (pp. 915-929).
Wuest, et al., Isozymes of Lactic Dehydrogenase and its Thermal Inactivation in the Diagnosis of Internal Maladies, Vol. 58, Chemical Abstracts 1963 (p. 11829h).
Nisselbaum et al., Immunochemical Studies of Human Lactic Dehydrogenases, Annals New York Academy of Sciences, 103, 1963 (pp. 930-937).
Merck Patent Gesellschaft mit beschrankter Haftung
Naff David M.
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