Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-09-28
1998-02-10
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 721, 435 792, 435975, 436516, 436518, 436531, 4241841, 424569, 530350, 530512, 530513, G01N 3353, G01N 33561, A61K 3900, C07K 100
Patent
active
057167877
ABSTRACT:
Antibodies that are indicative of organ transplant rejection, for example, cardiac or kidney transplant rejection, and of associated pathological conditions, for example, accelerated (or transplant-associated) coronary artery disease (CAD) are identified, as are antigens that bind to such antibodies. The antigens are used in immunoassays to diagnose transplant rejection and associated pathological conditions, and in the treatment of transplant rejection. The antigens and antibodies are particularly useful in the diagnosis and treatment of chronic rejection and associated conditions, especially rapid onset vasculopathy.
REFERENCES:
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Eisen et al as cited in parent application No. 08/040500.
Bradd et al. "Detection of Endothelial Antibodies by Western Blotting-Positive Correlation with the Occurrence of Coronary Artery Disease After Cardiac Transplantation", Journal of Heart and Lung Transplantation, abstract, 12th annual meeting, International Society for Heart Transplantation, Apr. 2-4, 1992, published in the Jan./Feb. supplement of the Journal of Heart and Lung Transplantation.
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Dunn Michael John
Rose Marlene Lydia
National Heart and Lung Institute
Smith Lynette F.
Stucker Jeffrey
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