Immunological compounds

Details Immunological compounds Immunological compounds

1975-09-15

1977-04-12

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, A23J 106

Patent

active

040174719

ABSTRACT:
The present invention relates to an antitumor agent comprising p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride bound to a tumor specific antibody by peptide bonds. The antitumor agent of the present invention is prepared by reacting a cytotoxic agent, p-di(2-chloroethyl)amino-L-phenylalanine or N,N-bis(2-chloroethyl)p-phenylenediamine hydrochloride with a tumor specific antibody in the presence of a water soluble carbodiimide such as 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and thereby forming a peptide bond between the cytotoxic agent and the tumor specific antibody.

REFERENCES:
patent: 3639558 (1972-02-01), Csizmas
patent: 3709868 (1973-01-01), Spector
patent: 3903262 (1975-09-01), Pappenhagen

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