Immunological composition of measles virus utilizing recombinant

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

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4353201, 4351723, 4241991, 4242111, 4242121, 4242321, 530350, C12N 700, C12N 1500, A61K 3912, A61K 39155

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057598410

ABSTRACT:
What is described is a recombinant poxvirus, such as vaccinia virus or canarypox virus, containing foreign DNA from Morbillivirus. In one embodiment, the foreign DNA is expressed in a host by the production of a measles virus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two measles virus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, cross-protection of dogs against canine distemper is obtained by inoculating the dog with the recombinant poxvirus.

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