Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1996-02-26
1999-01-05
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
436 69, 530381, C12Q 156
Patent
active
058561145
ABSTRACT:
The present invention is directed to immunochemical detection procedures, e.g., using both Western blotting and direct immunoassays, for fragments of Factor Va, which can thus be used; (a) in a predictive manner to evaluate the existence and/or extent of a thrombotic complication; (b) to monitor the efficacy of prophylaxis for a thrombotic condition; and (c) as a means to evaluate potential risk of hemorrhage during thrombolytic therapy.
REFERENCES:
patent: 5049491 (1991-09-01), Mann et al.
Odegaard et al. "Proteolysis of Factor Va by Factor Xa and Activated Protein C", The Journal of Biological Chemistry, vol. 262, No. 23 (Aug. 15, 1987), pp. 11233-11238.
Guinto et al. "The Complete cDNA Sequence of Bovine Coagulation Factor V", The Journal of Biological Chemistry, vol. 267, No. 5 (Feb. 15, 1992), pp. 2971-2978.
R.J. Jenny et al. "Complete cDNA and derived amino sequence of human factor V", Proc. Natl. Acad. Sci. USA, Biochemistry, vol. 84, pp. 4846-4850, 1987 (Jul).
M. Kalafatis et al. "The Mechanism of Inactivation of human Factor V and Human Factor Va by Activated Protein C", The Journal of Biological Chemistry, vol. 269, No. 50, pp. 31869-31880, 1994 (Dec).
M. Kalafatis et al. "Characterization of the Molecular Defect in Factor V.sup.R506Q ", The Journal of Biological Chemistry, vol. No. 8, pp. 4053-4057, 1995 (Feb.).
M. Kalafatis et al. "Biochemical Prototype for Familial Thrombosis", Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, No. 12, 1995 (Dec).
Omar M.N. et al., "Inactivation of Factor Va by Plasmin." Journal of Biological Chemistry 262 (20): 9750-55, 1987.
Odegaard B. et al., "Proteolysis of Factor Va by Factor Xa and Activated Protein C." Journal of Biological Chemistry 262 (23): 11233-11236.
Guinto E. R. et al. , "The Complete DNA Sequence of Bovine Coagulation Factor V." Journal of Biological Chemistry 267 (5): 2971-2978, 1992.
Kalafatis Michael
Mann Kenneth G.
Buchanan Robert L.
Conlin David G.
Linek Ernest V.
Stucker Jeffrey
The University of Vermont
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