Immunologic chemotherapeutic agents comprising antigen binding d

Details Immunologic chemotherapeutic agents comprising antigen binding d Immunologic chemotherapeutic agents comprising antigen binding d

1976-05-25

1978-06-06

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424 85, 424 88, C07G 700

Patent

active

040936074

ABSTRACT:
Chemotherapeutic agents comprising an antigen binding dimer derived from an immunoglobulin covalently bound to a drug are disclosed. The dimer and drug are bound, while preserving both the antibody activity of the dimer and the pharmacological activity of the drug.

REFERENCES:
patent: 3850798 (1974-11-01), Sjoquist
patent: 3928580 (1975-12-01), Fontaine
patent: 3966898 (1976-06-01), Sjoquist et al.
patent: 3995018 (1976-11-01), Sjoquist
Scientific American, vol. 216, pp. 81-90 (1967), Porter et al.
Scientific American, vol. 223, pp. 34-42 (1970), Edelman.
Cancer Research, vol. 35, pp. 1175-1186, Hurwitz et al., 1975 (May).

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