Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-01-30
2007-01-30
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007930, C435S007940, C435S007950, C436S015000, C436S086000
Reexamination Certificate
active
09695919
ABSTRACT:
The invention relates to a process for detecting or determining a C-peptide-containing impurity in a sample of recombinantly produced human insulin or a derivative thereof, by a non-radioactive assay, comprising the steps:(a) preparing a sample of recombinantly produced human insulin or a derivative thereof;(b) mixing the samples with dilution buffer;(c) adding a tracer to mixture (b);(d) adding antibody specific for the C-peptide impurity to mixture (c);(e) adding “C-peptide second antibody bead” having at least one label to mixture (d); and(f) detecting or determining the presence of the C-peptide-containing impurity.
REFERENCES:
patent: 5811266 (1998-09-01), Newgard
patent: 6444641 (2002-09-01), Flora
patent: 6635745 (2003-10-01), Sedrani et al.
patent: 0 484 961 (1992-05-01), None
Campbell Alice section 1.3.4. p. 29; Monoclonal Antibody Technology (1984) Elsevier Science Publishers).
Naithani et al. Syntheses of monkey C-peptide derivatives Fed. Rep. Ger. International Congress Series (1979) 468: 94-98.
Iizuka et al. An Improved method for determination of human C-peptide in serum and urine. Biomedical Research (1990) 11: 417-423.
International Search Report to PCT/EP 00 10482 (May 7, 2001).
Derwent Abstract—WO 98/59246, abstract only.
V.K. Naithani & L.G. Heding, “Synthesis of Monkey C-Peptide Derivatives,”Proceedings of the Symposium on Proinsulin, Insulin, and C-Pepetide, Tokushima, Japan, Jul. 12-14, 1978, S. Baba et al., Eds., Exerpta Medica, Amsterdam-Oxford, pp. 94-98 (1979).
Gerl Martin
Steinert Cornelia
Cheu Jacob
Le Long V.
Nelligan Mark C.
Sanofi-Aventis Deutschland GmbH
LandOfFree
Immunologic assay to determine C-peptide containing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunologic assay to determine C-peptide containing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunologic assay to determine C-peptide containing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3763448