Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2006-11-14
2006-11-14
Yaen, Christopher (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S450000, C514S034000, C514S04400A, C530S387100, C530S387300, C530S388220
Reexamination Certificate
active
07135177
ABSTRACT:
The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab' domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lipid, and a polyethylene glycol derivatized lipid. The invention also provides for growth-inhibiting immunoliposomes that lack growth-inhibiting therapeutic agents and yet are capable of inhibiting the growth and proliferation of target cells.
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Benz Christopher C.
Hong Keelung
Kirpotin Dmitri
Papahadjopoulos Demetrois
Park John W.
The Regents of the University of California
Townsend and Townsend / and Crew LLP
Yaen Christopher
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