Immunointeractive molecules and uses thereof

Details Immunointeractive molecules and uses thereof Immunointeractive molecules and uses thereof

2005-06-10

2011-11-15

Rooney, Nora (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S275100, C435S810000, C514S001100, C530S350000

Reexamination Certificate

active

08057800

ABSTRACT:
The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having peanut allergy, or allergy to other tree nuts, and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having an allergy to the Ara h 2 allergen. The molecules of the present invention are useful in the development of diagnostic, therapeutic and prophylactic agents for conditions characterized by an aberrant, inappropriate or otherwise unwanted immune response to Ara h 2 or derivative or homologue thereof.

REFERENCES:
patent: 5558869 (1996-09-01), Burks, Jr. et al.
patent: 5973121 (1999-10-01), Burks, Jr. et al.
patent: 6441142 (2002-08-01), Burks, Jr. et al.
patent: 2003/0202980 (2003-10-01), Caplan et al.
patent: WO 97/24139 (1997-07-01), None
patent: WO 99/38978 (1999-08-01), None
patent: WO 99/45961 (1999-09-01), None
patent: WO 00/51647 (2000-08-01), None
patent: WO 00/52154 (2000-09-01), None
patent: WO 00/54803 (2000-09-01), None
patent: WO 01/36621 (2001-05-01), None
patent: WO 01/39799 (2001-06-01), None
patent: WO 01/40264 (2001-06-01), None
patent: WO 01/40264 (2001-07-01), None
patent: WO 03/037172 (2003-05-01), None
Sen M. et al., “Protein Structure Plays a Critical Role in Peanut Allergen Stability and May Determine Immunodominant IgE-Binding Epitopes”,The Journal of Immunology 169:882-887 (2002).
Burks A.W. et al., “Epitope Specificity of the Major Peanut Allergen,Ara h II”, Journal of Allergy and Clinical Immunology 95:607-611 (1995).
Chatel J-M et al., “Isolation and Characterization of Two Complete Ara h 2 Isoforms cDNA”,International Archives of Allergy and Immunology 131(1):14-18 (2003), together with STN FILE CA Abstract No. 139:379907.
Bayer K. et al., “Measurement of Peptide-Specific IgE as an Additional Tool in Identifying Patients With Clinical Reactivity to Peanuts”,Journal of Allergy and Clinical Immunology 112(1)202-207 (2003), together with STN FILE CA Abstract No. 139:259597.
Viquez O.M. et al., “Isolation and Molecular Characterization of the First Genomic Clone of Major Peanut Allergen, Ara h 2”,Journal of Allergy and Clinical Immunology 107(4):713-717 (2001), together with STN FILE CA Abstract No. 139:101378.
Li X-M et al., “A Murine Model of Peanut Anaphylaxis: T- and B-Cell Responses to a Major Peanut Allergen Mimic Human Responses”,Journal of Allergy and Clinical Immunology 106(1, Pt 1):150-158 (2000), together with STN FILE CA Abstract No. 134:146305.
Kleber-Janke T. et al., “Use of Modified BL21 (DE3)Escherichia coliCells for High-Level Expression of Recombinant Peanut Allergens Affected by Poor Condon Usage”,Protein Expression and Purification 19(3):419-424 (2000), together with STN FILE CA Abstract No. 133:265668.
Stanley J.S. et al., “Identification and Mutational Analysis of the Immunodominant IgE Binding Epitopes of the Major Peanut AllergenAra h 2”, Archives of Biochemistry and Biophysics 342(2):244-253 (1997), together with STN FILE CA Abstract No. 127:120896.
Gruber P. et al., “Influence of the Maillard Reaction on the Allergenicity of rAra h 2, a Recombinant Major Allergen from Peanut (Arachis hypogaea), Its Major Epitopes, and Peanut Agglutinin”,Journal of Agricultural and Food Chemistry 53(6):2289-2296 (2005), together with STN FILE CA Abstract No. 142:391170.
Glaspole I.N. et al., “Characterization of the T-Cell Epitopes of a Major Peanut Allergen, Ara h 2”,Allergy 60:35-40 (2005).
Gruber P. et al., “Development of an Epitope-Specific Analytical Tool for the Major Peanut Allergen Ara h 2 Using a High-Density Multiple-Antigenic Peptide Strategy”,Molecular Nutrition and Food Research 48(6):449-458 (2004), together with STN FILE CA Abstract No. 142:174809.

Affiliated with

Also associated with

Rating

Immunointeractive molecules and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunointeractive molecules and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunointeractive molecules and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4298200