Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-01-06
1998-12-08
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 721, 435 723, 435 77, 435 772, 435 78, 435 79, 435 791, 435 792, 435 4052, 435 4051, 435 405, 5303871, 530350, 5303877, G01N 33567, G01N 33574, G01N 3353, C07K 1600
Patent
active
058467394
ABSTRACT:
A method of determining the proliferative status of a carcinoma is disclosed. One obtains a patient sample and then quantitatively analyzes the sample for NGAL gene expression product. The amount of NGAL expression product is compared with a standard curve to determine the S-phase value. The sample can be breast tissue or breast fluid aspirate. Alternatively, blood can by analyzed for this marker to diagnose metastasis.
REFERENCES:
Abstract of S. Stoesz et al. "Overexpression of neu-related lipocalin (NRL) in neu-initiated but not ras or chemically initiated rat mammary carcinomas",Chemical Abstracts + Indexes, vol. 5, No. 124, 29 Jan. 1996, p. 870.
Abstract of S. Stoesz et al. "Indentification of a Lipocalin Uniquely Overexpressed in Neu-Initiated Rat Mammary Carcinomas", Proceedings of the Annual Meeting of the American Association for Cancer Research, San Francisco, Apr.10-13. 1994, p. 150.
L. Kjeldsen et al., "Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils", 2 J. Immuno. Meth. 155-164 (Nov. 13, 1996).
S. Bartsch, et al., Cloning And Expression Of Human Neutrophil Lipocalin cDNA Derived From Bone Marrow And Ovarian Cancer Cells, 357 FEBS Letters 255-259 (1995).
J. Bundgaard, et al., Molecular Cloning And Expression Of A cDNA Encoding NGAL A Lipocalin Expressed in Human Neutrophils, 202 Biochem. & Biophy. Res. Comm. 1468-1475 (1994).
L. Kjeldsen, et al., Isolation And Primary Structure Of NGAL, A Novel Protein Associated With Human Neutrophil Gelantinase, 268 J. Bio. Chem. 10425-10432 (1993).
S. Stoesz, et al., Isolation Of A Lipocalin Uniquely Overexpressed In Neu-Initiated Rat Mammary, AACR Abstract (1994).
S. Stoesz, et al., Cloning Of Genes Overexpressed In Neu-Initiated Rat Mammary Tumors, AACR Abstract (1992).
S. Xu, et al., The Development Of An Assay For Human Neutrophil Lipocalin (HNL)-To Be Used As A Specific Marker Of Neutrophil Activity In Vivo And Vitro, 171 J. Immu. 245-252 (1994).
N. L. Petrakis, Nipple Aspirate Fluid In Epidemiologic Studies Of Breast Disease, 15 Epid. Rev. 188-195 (1993).
F. Hutchinson, et al., Simple And Complex Cell Cycles, 5 Animal Review 341-95 (1989).
Gould Michael N.
Stoesz Steven P.
Feisee Lila
Lucas John
Wisconsin Alumni Research Foundation
LandOfFree
Immunohistochemical detection assay for carcinoma proliferative does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunohistochemical detection assay for carcinoma proliferative , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunohistochemical detection assay for carcinoma proliferative will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-175911