Immunoglobulins devoid of light chains

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435410, 8303871, 8303873, 83038822, 83038826, 8303884, 8303886, 8303917, 830866, C12P 2106, C12N 1563, C12N 504, C07K 1612

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058405267

ABSTRACT:
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.

REFERENCES:
Blier et al., "A Limited Number of B.intg.Cell Lineages Generates The Heterogeneity Of A Secondary Immune Response", J. Immunology, vol. 139, No. 12, pp. 3996-4006 (Dec. 15, 1987).
Websters II New Riverside University Dictionary, Riverside Publishing Co./Houghton Mifflin Co., Boston, Ma., 1995.
Hamers--Casterman et al., "Nature", 363:466-48 (1993).
Roitt et al., "Immunology", Gower Medical Publishing, London, pp. 1.5 and 5.7 (1985).
Ward et al., "Nature", 341:544-546 (1989).

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