Immunoglobulins devoid of light chains

Details Immunoglobulins devoid of light chains Immunoglobulins devoid of light chains

1995-06-06

1998-11-24

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435410, 8303871, 8303873, 83038822, 83038826, 8303884, 8303886, 8303917, 830866, C12P 2106, C12N 1563, C12N 504, C07K 1612

Patent

active

058405267

ABSTRACT:
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.

REFERENCES:
Blier et al., "A Limited Number of B.intg.Cell Lineages Generates The Heterogeneity Of A Secondary Immune Response", J. Immunology, vol. 139, No. 12, pp. 3996-4006 (Dec. 15, 1987).
Websters II New Riverside University Dictionary, Riverside Publishing Co./Houghton Mifflin Co., Boston, Ma., 1995.
Hamers--Casterman et al., "Nature", 363:466-48 (1993).
Roitt et al., "Immunology", Gower Medical Publishing, London, pp. 1.5 and 5.7 (1985).
Ward et al., "Nature", 341:544-546 (1989).

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