Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-03-29
2010-12-28
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S133100
Reexamination Certificate
active
07858753
ABSTRACT:
The present invention concerns immunoglobulins, such as antibodies, which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and modulate the interaction between OSM and gp130. In typical embodiments, OSM is glycosylated. The invention also concerns antibodies that modulate the interaction between both Site II and Site III of OSM and their respective interacting partners. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
REFERENCES:
patent: 6706266 (2004-03-01), Life
patent: 6345667 (1994-12-01), None
patent: WO99/48523 (1999-09-01), None
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979).
MacCallum et al. J. Mol. Biol. (1996) 262, 732-745.
Pascalis et al. The Journal of Immunology (2002) 169, 3076-3084.
Casset et al. (2003) BBRC 307, 198-205.
Vajdos et al. Journal of Molecular Biology (2002) 320, 415-428.
Holm et al. Molecular Immunology (2007) 44, 1075-1084.
Chen et al. J. Mol. Bio. (1999) 293, 865-881.
Wu et al. J. Mol. Biol. (1999) 294, 151-162.
Mueller et al. (PNAS 1992) vol. 89. pp. 11832-11836.
Ogata, et al., “Oncostatin M is produced during pregnancy by decidual cells and stimulates the release of HCG,”Molecular Human Reproduction(Aug. 2000) 6(8): 75-757.
Carroll, et al., “Antagonism of the IL-6 cytokine subfamily—a potential strategy for more effective therapy in rheumatoid arthritis” Inflammation Research, (1997) 47(1):1-7.
Barton, et al. Cancer Cachexia is Mediated in Part by the Induction of IL-6 Like Cytokines From the Spleen, Cytokine, vol. 16, No. 6, Sep. 21, 2001, pp. 251-257.
Deller, et al., Crystal structure and functional dissection of the cytostatic cytokine oncostatin M, Structure, vol. 8, No. 8, 2000, pp. 863-874.
Plater-Zyberk, C., et al. Amelioration of Arthritis in Two Murine Models Using Antibodies to Oncostatin M, Arthritis & Rheumatism, vol. 44, No. 11, Nov. 2001, pp. 2697-2702.
Schildbach, et al., Modulation of Antibody affinity by a non-contact residue, Protein Science, 1993, 2, pp. 206-214.
Westendorf, et al., Groeth Regulatory Pathways in Myeloma, Journal of Immunology , 1996, 157: 3801-3088.
Ellis Jonathan Henry
Eon-Duval Alexandre
Germaschewski Volker
Plumpton Christopher
Rapson Nicholas Timothy
Fedon Jason C.
Glaxo Group Limited
Han William T.
Helms Larry R.
Natarajan Meera
LandOfFree
Immunoglobulins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunoglobulins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunoglobulins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4235181