Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-08-15
2000-02-29
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Vector, per se
536 231, 536 241, 536 2431, C12N 1511, C12N 1563, C07H 2104
Patent
active
060308303
ABSTRACT:
Compositions and methods for directing the synthesis of a particular human immunoglobulin isotype are provided. Nucleic acid molecules representing sense and antisense sequences of trans-spliced messenger ribonucleic acid molecules enhance or reduce, respectively, isotype recombination to IgE, IgA or IgG isotypes from an IgM isotype. Particular methods and compositions for the treatment of allergy and allergic reaction are described through inhibition of IgE.
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Van Meervelt, et al.,
Fujieda Shigeharu
Saxon Andrew
Zhang Ke
LeGuyader John L.
Shibuya Mark L.
The Regents of the University of California
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