Immunoglobulin superantigen binding to gp 120 from HIV

Details Immunoglobulin superantigen binding to gp 120 from HIV Immunoglobulin superantigen binding to gp 120 from HIV

1994-09-14

1997-11-25

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 435 72, 435 724, 435 792, 435974, C12Q 170

Patent

active

056911351

ABSTRACT:
VH3 and VH4 type immunoglobulins display superantigen-type binding affinity for the HIV gp120 envelope glycoprotein. VH3 and VH4 type antibody molecules, including IgG and IgM, are shown to suppress HIV infection in vivo and in vitro. Determining the level of such antibody molecules is correlated to the advancement of HIV disease state.

REFERENCES:
Goodglick et al, "Mapping the Ig Superantigen-Binding Site of HIV-1 gp120" Journal of Immunology, vol. 155, No. 11 (1995), pp. 5151-5159.
Berberian et al, "Immunoglobulin VH3 Gene Products: Natural Ligands for HIV gp120", Science, vol. 261, No. 5128 (1993), pp. 1588-1591.

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