Immunoglobulin-secreting human hybridomas from a cultured human

Details Immunoglobulin-secreting human hybridomas from a cultured human Immunoglobulin-secreting human hybridomas from a cultured human

1981-03-26

1984-05-29

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435241, 435948, C12N 500, C12N 1500, C12N 502, C12R 191

Patent

active

044515707

ABSTRACT:
Novel human lymphoblastoid cells and hybridomas derived therefrom are provided. The cells are a HGPRT negative human B-cell line. The cells are readily fusible with lymphoid cells to produce hybridomas which secrete human monoclonal antibodies.

REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
Croce et al., "The Use of Mouse-Human and Human-Human Hybridomas in Human Genetics and Immunology" Somatic Cell Genetics, Plenum Press (1982), pp. 55-68.
Croce et al., "Production of Human Hybridomas Secretina Antibodies to Measles Virus" Nature 288 (Dec. 4, 1980), pp. 488-489.
Levy et al., "Further Characterization of the W1-L1 and W1-L2 Lymphoblastoid Lines" Journal of the National Cancer Institute, 46 (1971), pp. 647.654.
Olsson et al., "Human-Human Hybridomas Producing Monoclonal Antibodies of Predefined Antigenic Specificity" Proceedings of the National Academy of Sciences U.S.A., 77 (9-1980), 5429-5431.
Nowinski et al., "Human Monoclonal Antibody Against Forssman Antigen" Science 210, (10/1980), pp. 537-539.

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