Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Derived from transgenic multicellular eukaryote
Patent
1996-01-16
1998-04-07
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Derived from transgenic multicellular eukaryote
514 21, 5303871, C07K 1600, A61K 3100, A61K 39395
Patent
active
057361363
ABSTRACT:
Intravascular introduction of pooled immunoglobulin is employed prior to xenotransplantation to extend the effective lifetime of the donor organ. In particular, intravenous administration of concentrated immunoglobulin for intravenous use (IVIg) by itself, or in combination with immunosuppressive agents is used to enhance the survival time of xenografts.
REFERENCES:
Glotz, D. et al., "Inhibition of Anti-HLA Antibodies AB Cytotoxicity and Synthesis by Intravenous Polyclonal Immunoglobulins IVIG", 25th Annual Meeting of the American Society of Nephrology, Baltimore, Maryland, USA, Nov. 15-18, 1992. J Am Soc Nephrol 3(3). 1992 860, XP002041267.
Magee et al. Therapeutic Immunology 1:45-58, 1994.
Platt et al., Connecticut Medicine 8:468-70, 1991.
Basta et al., The J. Clin Invest. 84:1974-81, 1989.
Bach et al, Transplantation Proc. 24:49-52, 1992.
Dalmasso et al. Clin Eup. Immunol. 86:31-35 1991.
Sullivan et al, New Engl J. Med. 323:705-712, 1990.
Platt et al., Immunology Today 11:450-456, 1990.
Somerville et al. Kidney Int'l. 44 Suppl. 42:5112-5121, Jun. 16, 1993.
Kahan et al. Immunological Reviews 136:29-49, 1993.
Kupin et al. Transplantation 40:601-604, 1985.
Cottler-Fox et al. Experimental Hematology 16:518, 1988.
Gale et al. Cancer 68(6 suppl.):1451-1453, 1991.
Schulak et al. J. Surg. Res. 25:562-571, 1978.
Auchincloss, Transplantation 46:1-20, 1988.
Sharabi et al. J. Exp. Med. 172:195-202, 1990.
Blanchette et al., "Role of Intravenous Immunoglobulin G in Autoimmune Hematologic Disorders", Seminars in Hematology, 29(No 3, Suppl 2):72-82 (1992).
Budde et al., "Reticuloendothelial System Fc-receptor Function in Patients with Immune Thrombocytopenia After Treatment with High Dose Intravenous Immunoglobulin", Scand. J. Haematol., 37:125-129 (1986).
Bussel, "The Use of Intravenous .gamma.-Globulin in Idiopathic Thrombocytopenic Purpura", Clinical Immunology and Immunopathology, 53:S147-S155 (1989).
Dodd, "Hepatitis C Virus, Antibodies, and Infectivity; Paradox, Pragmatism and Policy", Am. J. of Clinical Pathology, 97(1):4-6 (1992).
Mitra et al., "Elimination of Infectious Retroviruses During Preparation of Immunoglobulins", Transfusion, 26(4):394-397 (1986).
Siber et al., "Preparation of human Hyperimmune Globulin to Haemophilus Influenzae b, Streptococcus Pneumoniae, and Neisseria Meningitidis", Infection and Immunity, 45(1):248-254 (1984).
Bansal Geetha P.
Feisee Lila
SangStat Medical Corporation
Trecartin Richard F.
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