Immunoglobulin half-molecules and process for producing hybrid a

Details Immunoglobulin half-molecules and process for producing hybrid a Immunoglobulin half-molecules and process for producing hybrid a

1983-10-04

1984-09-11

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424 85, 424 88, 435188, A61K 39395, C07G 700

Patent

active

044709250

ABSTRACT:
A process for preparing covalent hybrid antibodies is provided. These antibodies are obtained by the ordered covalent hybridization of intact immunoglobulin molecules. The generation of half-molecules from different IgG antibodies by reductive or S-sulfonation selective cleavage is followed by the ordered association of the different half-molecules. The pure covalent hybrid antibodies as new substances are also provided along with IgG half-molecules.

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