Immunoglobulin half-molecules and process for producing hybrid a

Details Immunoglobulin half-molecules and process for producing hybrid a Immunoglobulin half-molecules and process for producing hybrid a

1982-05-05

1984-10-30

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, C07G 700, A61K 39395

Patent

active

044798954

ABSTRACT:
A process for preparing covalent hybrid antibodies is provided. These antibodies are obtained by the ordered covalent hybridization of intact immunoglobulin molecules. The generation of half-molecules from different IgG antibodies by reductive or S-sulfonation selective cleavage is followed by the ordered association of the different half-molecules. The pure covalent hybrid antibodies as new substances are also provided along with IgG half-molecules.

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