Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-07-12
1992-02-11
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530412, 530418, 530419, 530420, 424 858, C07K 324, A61K 3704
Patent
active
050876953
ABSTRACT:
An immunoglobulin-rich fraction containing IgG, IgA and IgM is prepared in high concentration (200 mg/ml) by contacting diluted serum with CuSO.sub.4, which is a source of strong positive ions, to produce a precipitate rich in immunoglobulins, whereafter the precipitate is washed with an EDTA chelating agent solution and then a solution of L-lysine.HCl and NaHCO.sub.3 is added to form a colloidal solution of the washed immunoglobulin precipitate.
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Wang et al, Parent of Formulations of Protions and Peptides: Stability and Stabilizers, vol. 42, No. 25, pp. 5-12 (1988).
Surgenor et al; Preparation and Properties of Serum and Plasma Proteins, XXXV A System of Protein Fractionation Using Zinc Complexes, Vox Sang, 5:272-296 (1960).
DeLaurentis Anthony J.
MCY Laboratories Canada, Inc.
Moezie F. T.
Rozycki Andrew G.
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