Immunoglobulin control region

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S024100

Reexamination Certificate

active

07029910

ABSTRACT:
This invention relates to a control region in human immunoglobulins, to parts thereof and to their use.

REFERENCES:
Larionov, et al. Highly selective isolation of human DNA from rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning. PNAS, 1996, vol. 93, pp. 13925-13930
Turgeon et al. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UgT2B genes and pseudogenes on chromosome 4. JMB, 2000. vol. 195, pp. 489-504.
Burke, David T., Georges F. Carle, Maynard V. Olson (May 1987) “Cloning of Large Segments of Exogenoms DNA into Yeast by Means of Artificial Chromosome Vectors”Science236:806-812.
Davies, Nicholas P. and Clare Huxley (1996) “Yac Transfer into Mammalian Cells by Cell Fusion” Chapter 24, in: Methods in Molecular Biology, vol. 54:281292, YAC Protocols, edited by D. Markie Humana Press Inc., Totowa, NJ.
Duff, Karen and Clare Huxley (1996) “Targeting Mutations to YACs by Homologous Recombination” Chapter 18,In: YAC Protocols, vol. 54:281-292, edited by D. Markie, Humana Press Inc., Totowa, NJ.
Johnston, John R. (1988) “Yeast genetics, molecular aspects” Chapter 5,In: I, Campbell and J.H. Duffus (ed.), Yeast, a practical approach, IRL Press, Oxford, England, p. 107.
Pachnis, Vassilis, Larysa Pevny, Rodney Rothstein, Frank Constantini (Jul. 1990). “Transfer of a yeast artificial chromosome carrying human DNA fromSaccharomyces cerevisiaeinto mammalian cells”Proc. Natl. Acad. Sci. USA87:5109-5113.
Pavin, William J., Philip Hieter, Roger H. Reeves (Aug. 1990) “Modification and Transfer into an Embryonal Carcinoma Cell Line of a 360-Kilobase Human-Derived Yeast Artificial Chromosome”Molecular and Cellular Biology10(8):4163-4169.

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