Immunoglobulin conjugates of 2',2'-difluronucleosides

Details Immunoglobulin conjugates of 2',2'-difluronucleosides Immunoglobulin conjugates of 2',2'-difluronucleosides

1987-11-23

1989-03-21

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, 530391, A61K 3170, C07H 1700

Patent

active

048144380

ABSTRACT:
Immunoglobulin conjugates are formed by reacting a difluoronucleoside with an immunoglobulin via an alkane dioic acid linking group.

REFERENCES:
patent: 4692434 (1987-09-01), Hertel
Blair, et al., "Linkage of Cytotoxic Agents to Immunoglobulins," J. Immunological Methods, 59, 129 (1983).
Ghose, et al., "Preparation of Antibody-Linked Cytotoxic Agents," Methods Enzymology, 93, 280 (1983).
Hurwitz et al., J. Med. Chem. 28, 137-40 (1985).
Halmos et al., Carbohydrate Res. 156, 256-63 (1986).
Hurwitz, Biopolymers 22, 557-67 (1983).

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