Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-06-23
1989-07-04
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530387, 530389, 530402, 530405, 530406, 530828, 424 8591, A61K 39395, C07K 308
Patent
active
048452009
ABSTRACT:
A conjugate comprising a vinca moiety convalently linked at the 4-position via a group of the formula --OCOXCO-- where X represents a single chemical bond or an optionally substituted C.sub.1-10 chain, to an immunoglobulin or an immunoglobulin fragment.
The conjugates are useful in the treatment of cancer.
REFERENCES:
patent: 4507234 (1985-03-01), Kato et al.
Vitella et al, Science, 219, 644-650, Feb. 1983.
Rowland et al, Cancer Immunol. Immunother, 19: 1-7, (1985).
Cullinan George J.
Rowland George F.
Simmonds Robin G.
Conrad Robert A.
Kushan Jeff P.
Lilly Industries Limited
Moskowitz Margaret
Whitaker Leroy
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