Immunoglobulin binding protein

Details Immunoglobulin binding protein Immunoglobulin binding protein

2005-04-26

2005-04-26

Scheiner, Laurie (Department: 1648)

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

C530S413000, C435S007100, C435S007920

Reexamination Certificate

active

06884629

ABSTRACT:
The present invention is directed to an immunoglobulin light chain binding protein which comprises the amino acid sequence of SEQ ID NO:1 modified by an amino acid substitution at one or more of positions 39, 53 and 57 and/or by an amino acid insertion between positions 59 and 60 such that the dissociation constant (Kd) of the protein with respect to human immunoglobulin κ-chain is 400 nM or more at pH 8, or the amino acid sequence of a corresponding immunoglobulin light chain binding domain modified by an amino acid substitution at one or more of the positions equivalent to positions 39, 53 and 57 of SEQ ID NO:1 and/or by an amino acid insertion between positions equivalent to positions 59 and 60 of SEQ ID NO:1, such that the dissociation constant (Kd) of the protein with respect to human immunoglobulin κ-chain is 400 nM or more at pH 8, or the amino acid sequence of a fragment of (a) or (b) which contains at least one said substitution and/or insertion, such that the dissociation constant (Kd) of the protein with respect to human immunoglobulin κ-chain is 400 nM or more at pH 8.

REFERENCES:
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patent: WO 9322439 (1993-11-01), None
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