Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1989-09-08
1993-07-27
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530326, 530350, 530412, 530413, 530300, C07K 300, C07K 318, A61K 3702
Patent
active
052311678
ABSTRACT:
Polypeptides having a segment capable of binding to immunoglobulin heavy chain variable regions (V.sub.H) in an antigen independent manner have been described. These polypeptides can be used to form complexes with V.sub.M containing molecules for diagnostic purposes and to increase the affinity of the antibody for its antigen. Additionally, the polypeptides of the invention can be used to separate V.sub.H containing molecules from solution to form isolated V.sub.H or V.sub.H depleted compositions.
REFERENCES:
Maddon, et al. Cell, vol. 42, 93-104 (1985).
Guss, et al. The EMBO Journal, 5 1567-1575 (1986).
Uhlen, et al. Journal of Biol. Chem. 259 1695-1702 (1984).
Byrn, et al. Nature vol. 344 667-670 (1990).
Lamarre, et al. Science, vol. 245 743-746 (1989).
Golub Edward
Kroon Daniel
Lenert Petar
Zanetti Maurizio
Dreger Walter H.
Feisee Lila
Lacey David L.
The Regents of the University of California
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