Immunoglobulin-binding polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530326, 530350, 530412, 530413, 530300, C07K 300, C07K 318, A61K 3702

Patent

active

052311678

ABSTRACT:
Polypeptides having a segment capable of binding to immunoglobulin heavy chain variable regions (V.sub.H) in an antigen independent manner have been described. These polypeptides can be used to form complexes with V.sub.M containing molecules for diagnostic purposes and to increase the affinity of the antibody for its antigen. Additionally, the polypeptides of the invention can be used to separate V.sub.H containing molecules from solution to form isolated V.sub.H or V.sub.H depleted compositions.

REFERENCES:
Maddon, et al. Cell, vol. 42, 93-104 (1985).
Guss, et al. The EMBO Journal, 5 1567-1575 (1986).
Uhlen, et al. Journal of Biol. Chem. 259 1695-1702 (1984).
Byrn, et al. Nature vol. 344 667-670 (1990).
Lamarre, et al. Science, vol. 245 743-746 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Immunoglobulin-binding polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunoglobulin-binding polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunoglobulin-binding polypeptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2343010

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.