Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1990-06-20
1994-04-26
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530300, 530350, 5303871, C07K 1528, C07K 318, C07K 300, A61K 3702
Patent
active
053068122
ABSTRACT:
A method of separating V.sub.H containing immunoglobulins by admixing an immunoglobulin binding peptide is described. The polypeptide of the invention is capable of binding to heavy chain variable regions of antibodies in an antigen independent manner and can separate antigen/antibody complexes.
REFERENCES:
Maddon et al Cell vol. 42, 93-104, 1985.
Byrn et al. Nature vol. 344 667-670.
Nilsson et al Embo Journal 4, 1075-1080 1985.
Capon et al. Nature vol. 337, 9th Feb. 1989 pp. 525-530.
Guss, et al., The EMBO Journal, 5, 1567-1575 (1986).
Uhlen, et al., Journal of Biol. Chem. 259, 1695-1702 (1984).
Lamarre, et al., Science, vol. 245, 743-746 (1989).
Golub Edward
Kroon Daniel
Lenert Petar
Zanetti Maurizio
Dreger Walter H.
Feisee Lila
Lacey David L.
The Regents of the University of California
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