Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-06-14
1998-03-03
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 78, 435 79, 436501, 436513, 530413, G01N 33566
Patent
active
057233039
ABSTRACT:
The subject invention concerns a novel polynucleotide sequence cloned from emm2.2 gene of a Group A streptococcus, Type II strain which codes for an IgA-binding protein, ML2.2. The subject invention further concerns the novel IgA-binding protein. A process for producing the protein is given. The invention also concerns the protein in an immunoadsorbent and as a tracer for use in measuring and purifying IgA. Kits are given comprising the immunoadsorbent and the tracer form of the protein.
REFERENCES:
patent: 4757134 (1988-07-01), Blake et al.
patent: 4948725 (1990-08-01), Boyle
patent: 5210183 (1993-05-01), Lindahl et al.
Bessen, D.E., V.A. Fischetti (1990) "Differentiation between Two Biologically Distinct Classes of Group A. Streptococci by Limited Substitutions of Amino Acids within the Shared Region of M Protein-like Molecules" J. Exp. Med. 172:1757-1764.
Bessen, D., V.A. Fischetti (1990) "A Human IgG Receptor of Group A Streptococci is Associated with Tissue Site of Infection and Streptococcal Class" The Journal of Infectious Diseases 161:747-754.
Khandke, K.M. et al. (1988) "Complete Amino Acid Sequence of Streptococcal PepM49 Protein, A Nephritis-associated Serotype" The Journal of Biological Chemistry 263(11):5075-5081.
Bessen, D.E., V.A., Fischetti (1992) "Nucleotide Sequences of Two Adjacent M or M-Like Protein genes of Group A Streptococci: Different RNA Transcript Levels and Identification of a Unique Immunoglobulin A-Binding Protein" Infection and Immunity 60(1):124-135.
Haanes, E.J., P.P. Cleary (1989) "Identification of a Divergent M Protein Gene and an M Protein-Related Gene Family in Streptococcus pyogenes Serotype 49" Journal of Bacteriology 171(12):6397-6408.
Jeppson, H., E. Frinthz, L.-O. Heden (1992) "Duplication of a DNA sequence homologous to genes for immunoglobulin receptors and M proteins in Streptococcus pyogenes" FEMS Microbiology Letters 92:139-146.
Lancefield, R.C. (1962):"Current Knowledge of Type-Specific M Antigens of Group B Streptococci" J. Immunol. 89:307-313.
Frithz, E., L.O. Heden, G. Lindahl (1989) "Extensive sequence homology between IgA receptor and M proteins in Streptococcus pyogenes" Molecular Microbiology 3(8):1111-1119.
Bessen, D., K.F. Jones, V.A. Fischetti (1989) "Evidence for Two Distinct Classes of Streptococcal M Protein and Their Relationship to Rheumatic Fever" J. Exp. Med. 169:269-283.
Bessen Debra E.
Fischetti Vincent A.
Rockefeller University
Saunders David
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