Immunogens for the production of cocaine-hydrolyzing catalytic a

Details Immunogens for the production of cocaine-hydrolyzing catalytic a Immunogens for the production of cocaine-hydrolyzing catalytic a

1994-06-13

1998-03-24

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241841, 4241941, 4351885, 546129, 558198, 560103, 560109, A61K 39385, C07D45112, C07F 902, C07C 6976

Patent

active

057309850

ABSTRACT:
Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine derivative, namely cocaine, and their linking to carrier proteins, for the purpose of using them as immunogens. The resulting immunogens elicit the formation in experimental animals of antibodies able to promote the hydrolysis of cocaine. Both these catalytic anti-cocaine antibodies and the immunogens themselves are potentially useful for the treatment of individuals seeking to avoid the pharmacological effects of cocaine and in diagnostic applications.

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