Immunogens containing peptides with an attached hydrophobic tail

Details Immunogens containing peptides with an attached hydrophobic tail Immunogens containing peptides with an attached hydrophobic tail

1988-01-29

1991-08-13

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530404, 530405, 530406, A61K 3929, A61K 39295, C07K 1702

Patent

active

050395220

ABSTRACT:
An immunogenic complex comprising a peptide containing a hydrophobic tail, the peptide being adsorbed to hepatitis B virus surface antigen via the hydrophobic tail. Such complex in a immunogenically effective amount when administered with a physiologically acceptable diluent and an adjuvant can serve as a vaccine.

REFERENCES:
patent: 3976767 (1976-08-01), Neurath
patent: 4578269 (1986-03-01), Morein
patent: 4818527 (1989-04-01), Thornton et al.
Hepatitis B Virus Surface Antigen (HBsAG) as Carrier for Synthetic Peptides Having an Attached Hydrophobic Tail, Molecular Immunology, vol. 26, No. 1, 1989, pp. 53-62; A. R. Neurath et al.
Journal of Experimental Medicine, vol. 167, Feb. 1988, pp. 658-663; G. H. Lowell et al., Peptides Bound to Proteosomes Via Hydrophobic Feet Become Highly Immunogenic Without Adjuvants.
Molecular Immunology, vol. 24, 1987, pp. 523-529; A. Machida et al.; A Synthetic Peptide Coded for by the PRE-S2 Region of Hepatitis B Virus for Adding Immunogenicity to Small Spherical Particles Made of the Product Of The S gene.
J. Gen. Virology, vol. 28, 1975, pp. 251-254, A. R. Neurath et al.; Hydrohobic Chromatography of Hepatitis B Surface Antigen on 1,9-Diaminononane or 1,10-Diaminodecane Linked to Agarose.
A. R. Neurath, S. B. H. Kent, "The PreS Region of Hepadnavirus Envelope Proteins", in K. Maramorosh, F. A. Murphy, A. J. Shatkin, eds., Advances in Virus Research, vol. 32, Orlando, Fla., Academic Press, (1987).
A. R. Neurath, S. B. H. Kent in Immunochemistry of Viruses, "The Basis of Sero-Diagnosis and Vaccines", pp. 324-357, eds. M. H. V. Van Regenmortel and A. R. Neurath, Elsevier, Amsterdam, (1985).
Lowell et al. (1988), J. Expt'l Med., 167:658-663.
Neurath et al., (1989), Mol. Immunol., 26:53-62.
Sanchez et al., (1983), J. Med. Virol., 11:115-124.

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