Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-05-16
1997-05-27
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
4241931, 514 8, 514 18, 514 23, 530300, 530330, 530385, 530403, A61K 39385, A61K 3814, C07K 14805
Patent
active
056329938
ABSTRACT:
The present invention provides immunogens for obtaining HbA.sub.1c -specific antibodies, which immunogens have the general formula: ##STR1## wherein M is 1 to 40, T is a carrier protein and A is a spacer which has a chain length of 10 to 20 atoms and has the general formula: ##STR2## wherein X is a sulphur atom or au --NH-- group, n is 1 to 4 and B is an organic radical which contains a succinimide group. The present invention also provides a process for obtaining antibodies which specifically bind glycosylated haemoglobin, wherein an immunogen of general formula (I) is injected into an organism capable of antibody formation and the antibodies are then obtained in known manner. These antibodies can be used for determining HbA.sub.1c in body fluids.
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patent: 4806468 (1989-02-01), Wagner et al.
The Merck Index, 9th edition, p. 463, "3475. Edestin", Merck and Co., Rahway, NJ 1976.
Batz Hans-Georg
Essig Ulrich
Hubner-Parajsz Christa
Kerscher Lorenz
Klein Christian
Boehringer Mannheim GmbH
Cunningham Thomas M.
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