Immunogenic synthetic peptide capable of eliciting herpes simple

Details Immunogenic synthetic peptide capable of eliciting herpes simple Immunogenic synthetic peptide capable of eliciting herpes simple

1987-04-10

1988-08-02

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530345, C07K 708

Patent

active

047614706

ABSTRACT:
A synthetic peptide, containing the predicted amino acid residues 64 to 77 of the herpes simplex virus type 1 (HSV1) gB structural glycoprotein open reading frame, a synthetic subunit immunogen that stimulates an immune response against HSV1 and which, when prepared, and chemically-conjugated to a protein carrier molecule, and inoculated into test animals, gives rise to a specific anti-peptide IgG response, such that these anti-peptide antibodies react with a purified HSV-specific structural glycoprotein preparation and are capable of neutralizing the infectivity of HSV1.

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patent: 4618578 (1986-10-01), Burke et al.
Virology, 135, 301-314, (1984), Bzik, et al.
J. Gen. Virol., (1982), 58, 217-222.
Emo Journal, 3, (1984), 3135-41, Everets.

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