Immunogenic peptides of human interleukin-1 and the correspondin

Details Immunogenic peptides of human interleukin-1 and the correspondin Immunogenic peptides of human interleukin-1 and the correspondin

1988-06-17

1991-02-19

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530300, 530351, 530806, 530402, 530403, 530405, 530810, 530812, 424 851, 424 852, 424 858, 514 2, 514 14, 514885, C07K 708, C07K 1700

Patent

active

049945530

ABSTRACT:
Several distinct peptide regions of the secreted form of purified human interleukin-1 species pI 6.8 have been found to exhibit characteristics associated with highly immunogenic protein moieties and are used to produce specific anti-peptide antibodies. The antibodies raised against the individual peptides are specific for the peptide used for their production and for IL-1, pI 6.8. The individual antibodies bind to both the precursor of IL-1, pI 6.8 and the mature or extracellular IL-1, pI 6.8.

REFERENCES:
patent: 4762914 (1988-08-01), Auron et al.
patent: 4766069 (1988-08-01), Auron et al.
patent: 4774320 (1988-09-01), Tayliabue et al.
Rimsky et al., LBC 136, 1986, pp. 3304-3310.
Dinarello et al., J. Immunol., 133, 9/84, p. 1332-13382.
Masliy et al., PNAS 84, 1987, pp. 4572-4576.
Regenmortel, TiB 11, 1986, pp. 36-39.
Shinnick et al., Ann Res. Microbiol, 1983, 37, pp. 425-446.
March et al., Nature, 315, 1985, pp. 641-647.

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