Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1984-09-11
1986-06-24
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530329, 530328, 530327, 530807, C07K 708, C07K 706, C07K 710
Patent
active
045966745
ABSTRACT:
Synthetic peptides, containing amino acid residues 15 to 21, 75-80 and 101-107 of the hepatitis A virus (HAV) VP1 structural protein sequence, was prepared and chemically conjugated to a protein carrier molecule. The peptide-carrier conjugate, when inoculated into test animals, gives rise to a specific anti-peptide IgG antibody response. These anti-peptide antibodies bind directly to intact hepatitis A virions, bind to purified and denatured VP1, compete with polyspecific antibody derived from human HAV immune sera, and are capable of neutralizing the infectivity of the virus. The peptide is useful as a synthetic subunit immunogen that stimulates an immune response against HAV.
REFERENCES:
Beale, Nature 298: 14-15, Jul. 1, 1982.
Arnon et al., Journal of Immunological Methods 61: 261-273, 83.
Shinnick et al., Ann. Rev. Microbiol 37: 425-446, 1983.
Emini et al., Nature 304: 699-703, 8/25/83.
Boger Joshua S.
Emini Emilio A.
Hughes Joseph V.
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
Phillips Delbert R.
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