Immunogenic detoxified mutant E. coli LT-A toxin

Details Immunogenic detoxified mutant E. coli LT-A toxin Immunogenic detoxified mutant E. coli LT-A toxin

2007-11-06

2007-11-06

Borin, Michael (Department: 1631)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C424S278100, C424S282100

Reexamination Certificate

active

10304496

ABSTRACT:
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of anE. coliheat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72 of the A subunits mutated, preferably by substitution with Arg. The toxoid is useful as vaccine against an enterotoxigenic strain ofE. coliand is produced by recombinant DNA means by site-directed mutagenesis. It is also an effective adjuvant.

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