Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin sub

Details Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin sub Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin sub

1984-08-10

1989-02-28

Tanenholtz, Alvin E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530807, 530812, 530808, 424 92, 435 6, 4351723, 435320, 43524027, 935 12, 514 12, C07K 1700, C07K 1500, A61K 3902, C12Q 168, C12N 1500, C12N 100, C12N 500

Patent

active

048087009

ABSTRACT:
A conjugate, which is the reductive amination product of an immunogenic capsular polymer fragment, having a reducing end and derived from the capsular polymer of a bacterial pathogen, and the non-toxic polypeptide binding subunit of the heat-labile enterotoxin of Escherichia coli (LT-BNT). Also disclosed, are methods for the preparation of the conjugates and for the preparation of vaccines containing the conjugates which elicits an effective level of antibodies in humans. By administering an immunogenic amount of the conjugates, active immunization against systematic infection in young mammals caused by bacterial pathogens can be induced.

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