Immunogenic conjugates comprising leukotoxin peptide fragments

Details Immunogenic conjugates comprising leukotoxin peptide fragments Immunogenic conjugates comprising leukotoxin peptide fragments

1988-06-29

1991-07-02

Doll, John

Drug, bio-affecting and body treating compositions

Lymphokine

424 87, 424 88, 424 92, 530327, 530345, 530350, 530807, A61K 39385, A61K 39395, A61K 39102, A61K 3940

Patent

active

050284231

ABSTRACT:
Conjugate immunogens are disclosed, comprising peptide fragments having substantial homology to the N-terminal region of Pasteurella haemolytica leukotoxins, covalently linked to suitable carrier proteins.

REFERENCES:
patent: 4474757 (1984-10-01), Arnon et al.
patent: 4591552 (1986-05-01), Neurath
Confer, et al., "Serum Antibodies to Pasteurella haemolytica Lipopolysaccharide: Relationship to Experimental Bovine Pneumonic Pasteurellosis", Am J Vet Res, 47:1134-1138 (1986).
Gentry, et al., "Serum Neutralization of Cytotoxin from Pasteurella Haemolytica, Serotype 1 and Resistance to Experimental Boving Pneumonic Pasterurellosis", Vet Imm & Immunopathology, 9:239-250 (1985).
Himmel, et al., "Purification and Partial Characterization of a Macrophage Cytotoxin from Pasteurella Haemolytica", Am J Vet Res, 43:764-767 (1982).
Chang, et al., "Pasteurella Haemolytica Leukotoxin: Physicochemical Characteristics and Susceptibility of Leukotoxin to Enzymatic Treatment", Am J Vet Res, 47:716-723 (1986).
Chem Abstracts 104: "Cloning and Expression of the Leukotoxin Gene of Pasteurella Haemolytica Al in Escherichia coli K-12", 16066c (1986).
Sela et al., Handbook of Experimental Immunology, vol. 1, Immunochemistry, Weir (ed.), Blackwell Scientific Publications, Boston, pp. 2.1-2.12 (1986).
Makela et al., Handbook of Experimental Immunology, vol. I, Immunochemistry, Weir (ed.), Blackwell Scientific Publications, Boston, pp. 3.1-3.13 (1986).
Rudinger, Peptide Hormones, Parsons (ed.), U. Park Press, Baltimore, pp. 1-7 (1976).

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