Immunogenic compositions containing ordered carriers

Details Immunogenic compositions containing ordered carriers Immunogenic compositions containing ordered carriers

1990-03-02

1991-08-27

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 514 8, 530395, 530403, 530404, 530405, 530406, 530810, A61K 39385, C07K 1702

Patent

active

050431587

ABSTRACT:
Superior pharmaceutical compositions which comprise carriers coupled to epitope-bearing moieties are described. The carriers are crystalline or paracrystalline glycoproteins, especially those derived from S-layers of microbial cell walls. These conjugates are capable of eliciting the formation of antibodies as well as a T-cell response.

REFERENCES:
patent: 4578269 (1986-03-01), Morein
patent: 4801578 (1989-01-01), Monsigny et al.
patent: 4837171 (1989-06-01), Codington
Lovgren et al., (1987) J. Immunol. Methods, 98:137-143.
Gray (1978) Methods Enzymol., 50:155-160.
Warren et al., Ann. Rev. Immunol. (1986) 4:369-388.
Bellstedt et al., J. Immunol. Meth. (1987) 98:249-255.
Livingston et al., J. Immunol. (1987) 138(5):1524-1529.
Avrameas et al., Scand. J. Immunol. (1978) 8:7-23.
Makela et al., Scand. J. Immunol. (1984) 19:541-550.
Seizen et al., FEBS Letters (1979) 100(1):75-80.

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