Immunogenic compositions comprising progastrin and uses thereof

Details Immunogenic compositions comprising progastrin and uses thereof Immunogenic compositions comprising progastrin and uses thereof

2007-12-19

2010-12-21

Helms, Larry R. (Department: 1642)

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

C424S130100, C435S325000, C435S007230

Reexamination Certificate

active

07854932

ABSTRACT:
The present invention is drawn to immunotherapeutic methods to treat tumors/cancers that produce progastrin ectopically or are dependent on progastrin for their growth. Disclosed herein are immunogenic compositions comprising agents that target progastrin, agents that target the progastrin receptor, annexin II, or both. Such a composition may be administered in combination with chemotherapy or to an individual who had been previously subjected to chemotherapy or radiation therapy. The cancers that may be treated using such a composition may include but are not limited to colon cancer, breast cancer, lung cancer or pancreatic cancer.

REFERENCES:
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Sharma et al, Exp and Mol Path, 81:136-145, pub online, Apr. 2006.
Singh, P. et al. Gastrin Gene Expression is Required for the Proliferation and Tumorigenicity of Human Colon Cancer Cells.:Cancer Res., Sep. 15, 1996, vol. 56, No. 18, pp. 4111-4115.
Siddheshwar, RK et al. Plasma Levels of Progastrin but not Amidated Gastrin or Glycine Extended Gastrin are Elevated in Patients with Clolrectal Carcinoma:Gut, 2001, vol. 48, No. 1, pp. 47-52.
Madoiwa, S. et al. Annexin 2 and Hemorrhagic Disorder in Vascular Intimal Carcinomatosis:Thrombosis Research, 2007, vol. 119, No. 2, pp. 229-240.

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