Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1997-03-21
2000-10-10
Minnifield, Nita
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4242421, 4242341, 4241901, 424682, 530300, 530350, 530326, 530325, 514 2, 514 12, A61K 3900, A61K 3938, A61K 3800, C07K 1700
Patent
active
061299170
ABSTRACT:
Provided herein are methods and immunogenic compositions useful for protecting mammals from infection and pathology of P. gingivalis. Specifically, arginine-specific proteases of Porphyromonas gingivalis and peptides derived therefrom offer protection against infection. Immunogenic compositions comprising a 50 kDa arginine-specific protease, the high molecular weight complex or peptides from one of the foregoing proteins are capable of protecting against P. gingivalis infection and/or gingivitis and/or periodontitis caused thereby in mammals, including humans.
REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3939350 (1976-02-01), Kronick et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4275149 (1981-06-01), Litman et al.
patent: 4277437 (1981-07-01), Maggio
patent: 4366241 (1982-12-01), Tom et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5462734 (1995-10-01), Letchworth, III et al.
patent: 5475097 (1995-12-01), Travis et al.
patent: 5523390 (1996-06-01), Travis et al.
patent: 5536497 (1996-07-01), Evans et al.
patent: 5571531 (1996-11-01), McDermott et al.
patent: 5824791 (1998-10-01), Progulske-Fox et al.
patent: 5830710 (1998-11-01), Progulske-Fox et al.
Imamura et al, JBC, 272(25):16062-67, Jun., 1997.
Chen et al, Inf. & Imm, 59(8):2846-2850, Aug., 1991.
Pike et al, J. Bacterial, 178(10):2876-2882, May, 1996.
Jagels et al, Adv. Exp. Med. Biol. 389(Intracellular Protein Catabolism) 155-164, 1996.
Imamura et al. Inf. & Imm. 63(12): 4877-4882, Dec. 1995.
Jagels et al, Inf. & Imm. 64(6): 1984-1991, Jun. 1996.
Okamoto et al, Archives Biochem & Biophys. 316(2):917-925, Feb. 1995.
Imamura et al, Inf. & Imm, 63(5): 1999-2003, May 1995.
Agawa, J. Med. Microbiol, 41: 349-358, 1994.
Aduse-Opoku, J. et al. (1995), "Characterization, Genetic Analysis, and Expression of a Protease Antigen (PrpRI) of Porphyromonas gingivalis W50," Infect. Immun. 63(12):4744-4754.
Barkocy-Gallagher et al. (1996), "Analysis of the prtP Gene Encoding Porphypain, a Cysteine Proteinase of Porphyromonas gingivalis," J. Bacteriol. 178:2734-2741.
Chen et al. (1992), "Purification and Characterization of a 50-dKa Cysteine Proteinase (Gingipain) from Porphyromonas gingivalis," J. Biol. Chem. 267:18896-18901.
Curtiss et al. (1996), "Characterization of an Adherence and Antigenic Determinant of the ArgI Protease of Porphyromonas gingivalis Which is Present on Multiple Gene Products," Infect. Immun. 64:2532-2539.
Ebersole et al. (1984), "Serological Identification of Oral Bacteroides spp. by Enzyme-Linked Immunosorbent Assay," J. Clin. Microbiol. 19:639-644.
Ebersole et al. (1989), "Murine Model for Virulence Characteristics of Periodontopathogens," J. Dent. Res. 68:286, Abstract 837.
Genco et al. (1991), "A Novel Mouse Model to Study the Virulence of and Host Response to Porphyromonas (Bacteroids) gingivalis," Infect. Immun. 59:1255-1263.
Genco et al. (1992), "Influence of Immunization on Porphyromonas gingivalis Colonization and Invasion in the Mouse Chamber Model," Infect. Immun. 60:1447-1454.
Genco et al. (1995), "Resistance of a Tn4351-Generated Polysaccharide Mutant of Porphyromonas gingivalis to Polymorphonuclear Leukocyte Killing," Infect. Immun. 63(2):393-401.
Goulbourne and Ellen (1991), "Evidence that Porphyromonas (Bacteriodes) gingivalis Fimbriae Function in Adhesion to Actinomyces viscosus," J. Bacteriol. 173:5266-5274.
Gunsolley et al. (1990), "Serum Antibodies to Periodontal Bacteria," J. Periodontol. 61:412-419.
Hamada et al. (1994), "Construction and Characterization of a fimA Mutant of Porphyromonas gingivalis," Infect. Immun. 62:1696-1704.
Han, N. and Progulski-Fox, A. (1996), "The P. gingivalis 381 HagA Gene Contains 4 Contiguous Direct Repeats Each 1.35 kb in Length," J. Dent. Res. 75 (IADR Abstracts) #3225.
Lamont et al. (1992), "Characterization of the adherence of Porphyromonas gingivalis to oral streptococci," Oral Microbiol. Immunol. 7:193-197.
Lamont et al. (1993), "Involvement of Porphyromonas gingivalis fimbriae in adherence to Streptococcus gordonii," Oral Microbiol. Immunol. 8:272-276.
Malek et al. (1994), "Inactivation of the Porphyromonas gingivalis fimA Gene Blocks Periodontal Damage in Bnotobiotic Rats," J. Bacteriol. 176:1052-1059.
McArthur and Clark (1993), "Specific Antibodies and Their Potential Role in Periodontal Diseases," J. Periodontol. 64:807-818.
Naito et al. (1987), "Detection of Specific Antibody in Adult Human periodontitis Sera to Surface Antigens of Bacteriodes gingivalis," Infect. Immun. 55:832-834.
Okamoto et al. (1996), "Cloning and Sequencing of the Gene Encoding a Novel Lysie-Specific Cysteine Proteinase (Lys-Gingipain) in Porphyromonas gingivalis: Structural Relationship with the Arginine-Specific Cysteine Proteinase (Arg-Gingipain)," J. Biochem. 120:398-406.
Pavloff et al. (1995), "Molecular Cloning and Structural Characterization of the Arg-gingipain Proteinase of Porphyromonas gingivalis," J. Biol. Chem. 270:1007-1010.
Pike et al. (1994), "Lysine- and Arginine-specific Proteinases from Porphyromonas gingivalis," J. Biol. Chem. 269:406-411.
Potempa, J. et al. (1995), "The Multiple Forms of Trypsin-like Activity Present in Various Strains of Porphyromonas gingivalis are due to the Presence of Either Arg-Gingipain or Lys-Ginigpain," Infect. Immun. 63(4):1176-1182.
Potempa, J. et al. (1995), "Host and Porphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction," Perspectives in Drug Discovery and Design 2:445-458.
Potempa, J. et al. (1995), "Porphyromonas gingivalis: a proteinase/gene accounting audit," Trends Microbiol. 3(11):430-434.
Tokuda et al. (1996), "Role of Porphyromonas gingivalis Protease Activity in Colonization of Oral Surfaces," Infect. Immun. 64:4067-4073.
Turner et al. (1989), "Serum and gingival tissue antibody levels to oral microbial antigens in human chronic adult periodontitis," Microbios 60:133-140.
Wingrove et al. (1992), "Activation of Complement Components C3 and C5 by a Cysteine Proteinase (Gingipain-1) from Porphyromonas (Bacteroides) gingivalis," J. Biol. chem. 267:18902-18907.
Yoshimura et al. (1987), Detection of Specific Antibodies Against Fimbriae and Membrane Proteins from the Oral Anaerobe Bacteroides gingivalis in Patients with Periodontal Diseases, Microbiol. Immunol. 31:935-941.
Arnott et al., "Cloning and Expression of Porphyromonas (Bacteroides) gingivalis Protease Gene in Escherichia Coli," Archs. Oral Biol., 35(7) Suppl., 97S-99S, (1990).
Barrett et al. "Cathepsin B, Cathepsin H, and Cathepsin L," Methods in Enzymology, vol. 80, Proteolytic Enzymes, Part C, Lorand, ed., Academic Press, New York, NY, pp. 535-561 (1981).
Birkedal-Hansen et al., "Characterization of Collagenolytic Activity from Strains of Bacteroides gingivalis," J. Periodont. Res., 23(4), 258-264 (1988).
Bourgeau et al., "Cloning, Expression, and Sequencing of a Protease Gene (tpr) from Porphyromonas gingivalis W83 in Escherichia coli," Infect. Immun., 60(8), 3186-3192 (1992).
Carlsson et al., "Degradation of the Human Proteinase Inhibitors Alpha-1-Antitrypsin and Alpha-2-Macroglobulin by Bacteroides gingivalis," Infect. Immun., 43(2), 644-648 (1984).
Carlsson et al., "Degradation of Albumin, Haemopexin, Haptoglobin and Transferrin, by Black-Pigmented Bacteroides Species," J. Med. Microbiol., 18, 39-46 (1984).
Chua et al., "Sequence Analysis of cDNA Coding for a Major House Dust Mite Allergen, Der p 1, Homology with Cysteine Proteases," J. Exp. Med., 167, 175-182 (1988).
Dayhoff et al,. "A Model of Evolutionary Change in Proteins," Atlas of Protein Sequence and Structure, National Biomedical Research Foundation, Washington, D.C., vol. 5, Suppl. 3, pp. 345-352 (1978).
Deutscher, ed., Methods of Enzymology: vol. 182, Guide to Protein Purification, Academic Press, Inc., San Diego, cover page and table of contents (1990).
Discipio et al., "Cleavage of Human Complement Component C5 by Cysteine Proteinases from Porphyromonas (Bacteroides) gingivalis. Prior Oxidation of C5 Augments Proteinase Digestion of C5," Immunology, 87(4),
Genco Caroline Attardo
Potempa Jan
Travis James
Minnifield Nita
Morehouse School of Medicine
The University of Georgia Research Foundation Inc.
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