Immunogenic compositions capable of eliciting Th1 immune...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S208100, C424S278100

Reexamination Certificate

active

07611712

ABSTRACT:
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate (SEQ ID NOS: 1-3) on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NO: 1), messenger RNA, or DNA/RiNA (SEQ ID NOS:2-3). DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.

REFERENCES:
patent: 5443828 (1995-08-01), Kang et al.
patent: 5576421 (1996-11-01), Saito et al.
patent: 5817512 (1998-10-01), Morrow et al.
patent: 6627197 (2003-09-01), Keener
patent: WO 01/24810 (2001-04-01), None
patent: WO 2004002415 (2004-01-01), None
Mata, M., et al., 2001, “Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge”, Vaccine 19:1435-1445.
Flexner, C., et al., 1988, “Characterization of human immunodeficiency virus gag/pol gene products expressed by recombinant vaccinia viruses”, Virol. 166(2):339-349.
Azadegan, A. A., et al., 1984, “Cobra venom factor abrogates passive humoral resistance to syphilitic infection in hamsters”, Infect. Immun. 44(3):740-742.
HIV Immunology Epitope Search, Los Alamos Database, 2006.
Mata, M., et al., 2001, Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge, Vaccine 19:1435-1445.
Gowda, D. C., et al., 1994, Immunoreactivity and function of oligosaccharides in Cobra Venom Factor, J. Immunol. 152:2977-2986.
Frankel, F. R., et al., 1995, Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector, J. Immunol. 155:4775-4782.
Miller, M. A., et al., 1996, Protective immunity to Listeria monocytogenes elicited by immunization with heat-killed Listeria and IL-12, Annals N.Y. Acad. Sci. 797:207-227 (abstract provided).
Human Retroviruses and AIDS 1999: A compilation and analysis of nucleic acid and amino acid sequences. Kuiken, C. L., et al., eds., Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, HIV/SIV Gag sequence compendium, pp. 332-341.
Aiken, C. et al., “Inside-out Regulation of HIV-1 Particle Fusion,” Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections, Boston, MA USA Abstract 17 (Feb. 10-14, 2003).
Aroeti, Benjamin, et al., Mutational and Secondary Structural Analysis of the Basolateral Sorting Signal of the Polymeric Immunoglobulin Receptor, J. Cell Biology, vol. 123, No. 5, 1149-1160 (1993).
Ara, Yuki, et al., “Zymozan enhances the immune response to DNA vaccine for human immunodeficiency virus type-I through the activation of complement system” Immunology 103: 98-105 (2001), Japan.
Aslam, Mohammed, et al., “Folded Back Solution Structure of Monomeric Factor H of Human Complement by Synchrotron X-ray and Neutron Scattering, Analytical Ultracentrifugation and Constrained Molecular Modelling,” Molecular Biology, vol. 309, pp. 1117-1138 (2001).
Ault, Bettina, et al., “Human Factor H Deficiency,” Biological Chemistry, vol. 272, #40, pp. 25168-25175 (1997), USA.
Blackmore, T. K., et al., “Identification of a Heparin Binding Domain in the Seventh Short Consensus Repeat of Complement Factor H,” Immunology, vol. 157, Iss 12, pp. 5422-5427 (1996).
Braaten, D., et al., “Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting of human T Cells,” The EMBO Journal, vol. 20, No. 6, pp. 1300-1309, 2001.
Brooks, Geo. F., Medical Microbiology Ch. 3 & 7 (23rd Ed. 2004).
Burger, R., et al., “Activation of the alternative pathway of complement: efficient fluid-phase amplification by blockade of the regulatory complement protein B1H through sulfated polyanions,” European J. Immunology, vol. 11, pp. 291-295 (1981).
Doepper, Susi, et al, “Complement Receptors in HIV Infection,” Current Molecular Medicine, vol, 2, Iss 8, pp. 703-711 (2002).
Burger, R., et al., “Dextran Sulphate: a Synthetic Activator of C3 via the Alternative Pathway,” Immunology, vol. 29. pp. 549-554 (1975).
Burger, R., et al., “Insoluble polyanions as activators of both pathways of complement,” Immunology 33:827-837 (1977).
Chan, D. C., et al., “Core Structure of gp41 from the HIV Envelope Glycoprotein” Cell, vol. 89, Issue 2, pp. 263-273 (Apr. 18, 1997).
Chen, Chien-Hung, et al., “Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to an HSP70 Gene,” Cancer Research 60:1035-1042 (Feb. 15, 2000).
Cheng, Wen-Fang, et al., “Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen,” Journal of Clinical Investigation, vol. 108, No. 5, 669-678 (Sep. 2001).
Hung, Chien-Fu, et al., “Enhancing Major Histocompatibility Complex Class I Antigen Presentation by Targeting Antigen to Centrosornes,” Cancer Research 63: 2393-2398 (May 15, 2003).
Cohen, P.T., The AIDS Knowledge Base, 15-18, 21 (3rd ed. 1999).
Cummings, Melissa, et al., New Research Uncovers Potential for More Effective Anti-HIV Therapies: Essential Role of Cyclophilin, Novel Non-Mutable Drug Target Discovered, PR NewsWire 1996.
Dierich, M. P., et al., “HIV and human complement: mechanisms of interaction and biological implication,” Immunology Today, vol. 14, Iss 9, pp. 435-440 (1993).
Discipio, R. G., “Ultrastructures and interactions of complement factors H and I,” J. Immunology, vol. 149, Iss 8, pp. 2592-2599 (1992).
Fearon, D.T., et al., “Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms,” Proc. Natl. Acad. Sci, vol. 74, No. 4, pp. 1683-1687 (Apr. 1977).
Feifel, Elisabeth, et al., “Polymorphism and deficiency of human factor H-related proteins p39 and p37,” Immunogenetics, vol. 36, pp. 104-109 (1992).
Fishelson, Z., et al., “C3 Convertase of Human Complement: Enhanced Formation and Stability of the Enzyme Generated with Nickel instead of Magnesium,” J. of lmmun., vol. 129, No. 6, pp. 2603-2607 (Dec. 1982).
Forrest, Bruce D., et al., “Effect of Parenteral Immunization on the Intestinal Immune Response to Salmonella typhy Ty21a,” Infection and Immunity, vol. 60, No. 2, pp. 465-471 (Feb. 1992).
Franke, E. K., et al., “Chaperoning a pathogen,” Nature, 372 (6504): 319-20 (Nov. 24, 1994).
Franke, E. K., et al., “Specific Incorporation of Cyclophilin A Into HIV-1 Virions,” Nature, 372(6504): 359 (Nov. 24, 1994).
Friese, M. A., “FHL-1/reconectin and factor H: two human complement regulators which are encoded by the same gene are differently expressed and regulated,” Molecular Immunology, vol. 36, pp. 809-818 (1999).
Furie, Bruce, “Oral Anticoagulant Therapy,” Hematology Basic Principles & Practice, Ch. 121. pp. 2040-2046 (3rd ed. 2000).
Gardner, William D., “Identification of a major human serum DNA-binding protein as B1H of the alternative pathway of complement activation,” Biochemical and Biophysical Research Communications, vol. 94, pp. 61-67 (1980).
Gasque, P., “Expression of complement components of the alternative pathway by glioma cell lines,” Immunology, 149:1381-87 (1992).
Giannakis, Eleni, et al., “Multiple ligand binding sites on domain seven of human complement factor H,” Int'l Immunopharmacology, vol. 1, Issue 3, pp. 433-443 (2001).
Goudsmit, J., Immunodominant B-Cell epitopes of the HIV-1 envelope recognized by infected and immunized hosts, AIDS, vol. 2 (Suppl I): S41-S45 (1988).
Gowda, D. C., et al., “Immunoreactivity and Function of Oligosaccharides in Cobra Venom

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