Immunogenic compositions and methods of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

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07807632

ABSTRACT:
Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.

REFERENCES:
patent: 5138026 (1992-08-01), Miyasaka et al.
patent: 5629213 (1997-05-01), Komguth
patent: 5981170 (1999-11-01), Trojnar et al.
patent: 6020175 (2000-02-01), Onda et al.
patent: 6479146 (2002-11-01), Caruso et al.
patent: 6689478 (2004-02-01), Laguitton
patent: 6743521 (2004-06-01), Hubbell et al.
patent: 6833192 (2004-12-01), Caruso et al.
patent: 7033797 (2006-04-01), Jansen et al.
patent: 7045146 (2006-05-01), Caruso et al.
patent: 7056554 (2006-06-01), Voigt et al.
patent: 7101575 (2006-09-01), Donath et al.
patent: 2004/0013721 (2004-01-01), Antipov et al.
patent: 2004/0241202 (2004-12-01), Chluba et al.
patent: 2005/0069950 (2005-03-01), Haynie
patent: 2005/0100883 (2005-05-01), Wang et al.
patent: 2005/0180945 (2005-08-01), Chaikof et al.
patent: 9308766 (1993-05-01), None
patent: WO 2006089572 (2006-08-01), None
Zhou et al. (“Protein microarrays on hybrid polymeric thin films prepared by self-assembly of polyelectrolytes for multiple-protein immunoassays,” Proteomics 2006, 6, 1415-1426).
Al, et al.; “Biomedical Applications of Electrostatic Layer-by-Layer Nano-Assembly of Polymers, Enzymes, and Nanoparticles”; Cell Biochemistry and Biophysics; 39; pp. 23-43; 2003.
Boulmedais, et al; “Buildup of Exponentially Growing Multilayer Polypeptide Films with Internal Secondary Structure”; Langmuir; 19; pp. 440-445; 2003.
Boura, et al; “Endothelial Cells Grown on Thin Polyelectrolyte Mutilayered Films: An Evaluation of a New Versatile Surface Modification”; Biomaterials; 24; pp. 3521-3530; 2003.
Chluba et al; “Peptide Hormone Covalently Bound to Polyelectrolytes and Embedded into Mutilayer Architectures Conserving Full Biological Activity”; Biomacromolecules; 2; pp. 800-805; 2001.
Glinel, et al.; “Polyelectrolyte Multilayers Based on Amphiphilic Polysaccharides: Application for Entrapment and Release of Hydrophobic Molecules”; Abstracts of Papers American Chemical Society, 230, p. U3590; 2005; Abstract.
Haynie, et al.; “Protein-Inspired Multilayer Nanofilms: Science, Technology and Medicine”; Nanomedicine: Nanotechnology, Biology, and Medicine; 2; pp. 150-157; 2006.
Jessel, et al; “Bioactive Coatings Based on Polyelectrolyte Multilayer Architecture Functionalized by Embedded Proteins”; Adv. Mater.; 15; pp. 692-695; 2003.
Lavalle, et al; “Comparison of the Structure of Polyelectrolyte Multilayer Films Exhibiting a Linear and an Exponential Growth Regime: An in Situ Atomic Force Microscopy Study”; Macromolecules; 35; pp. 4458-4465; 2002.
Li, et al.; “Multilayer Biomimetics: Reversible Covalent Stabilization of a Nanostructured Biofilm”; Biomacromolecules; 5; pp. 1667-1670; 2004.
Picart, et al; “Buildup Mechanism for Poly(L-lysine)/Hyaluronic Acid Films onto a Solid Surface”; Langmuir; 17; pp. 7414-7424; 2001.
Picart, et al; “Molecular Basis for the Explanation of the Exponential Growth of Polyelectrolyte Multilayers”; PNAS; 22; pp. 12531-12535; 2002.
Richert, et al; “Cell Interactions with Polyeletrolyte Multilayer Films”; Biomacromolecules; 3; pp. 1170-1178; 2002.
Tryoen-Toth, et al; “Viability, Adhesion, and Bone Phenotype of Osteoblast-like Cells on Polyelectrolyte Multilayer Films”; J. Biomed. Mater. Res.; 60; pp. 657-667; 2002.
Vautier, et al. “Polyelectrolyte Multilayer Films Moldulate Cytoskeletal Oranization in Chondrosarcoma Cells”; J. Biomater. Sci. Polymer Edn.; 13; pp. 713-732; 2002.
Zheng, et al.; “Design of Peptides for Thin Films, Coatings and Microcapsules for Applications in Biotechnology”; Journal of Biomaterials Science Polymer Edition 05; 16; pp. 285-299; 2005.
International Search Report; International Application No. PCT/US2006/041666; International Filing Date Oct. 25, 2006; Applicant's File Reference ATE-0004-2-PCT; Date of Mailing Jul. 4, 2007; 8 pages.
Written Opinion of International Searching Authority; International Application No. PCT/US2006/041666; International Filing DateOct. 25, 2006; Applicant's File Reference PCT/ISA/220; Date of Mailing Jul. 4, 2007; 9 pages.
Mozdzanowska, et al.; “Induction of Influenza Type A Virus-Specific Resistance by Immunization of Mice with a Synthetic Multiple Antigenic Peptide Vaccine that Contains Ectodomains of Matrix Proten 2”; Vaccine; 21; 2616-26; (2003).
Nadin, et al.; “Synthetic Malaria Peptide Vaccine Elicits High Levels of Antibodies in Vaccinees of Defined HLA Genotypes”; J. Infectious Diseases; 182; 1486-96; (2000).
Tam, et al.; “Vaccine Engineering: Enhancement of Immunogenicity of Synthetic Peptide Vaccines Related to Hepatitis in Chemically Defined Models Consisting of T- and B-cell Epitopes”; Proc. Natl. Acad. Sci. USA; 86; 9084-88; (1989).
Wang, et al; “Effective Synthetic Peptide Vaccine for Foot-and-Mouth Disease in Swine”; Vaccine; 20; 2603-10; (2002).
Alcaro et al; “Synthetic Peptides in the Diagnosis of HIV Infection”; Current Protein and Peptide Science; 4; pp. 285-290; (2003).
Ben-Yedidia et al; “Design of Peptide and Polypeptide Vaccines”; Current Opinion in Biotechnology; 8; pp. 442-448; (1997).
Brown et al; “Optimisation of a Peptide-Based Indirect ELISA for the Detection of Antibody in the Serum of HIV-1 Seropositive Patients”; Journal of Immunological Methods; 200; pp. 79-88; (1997).
Decher, Gero; “Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites”; Science; 277; pp. 1232-1237; (1997).
Giuliani et al; “A Universal Vaccine for Serogroup B Meningococcus”; Proc. Natl. Acad. Sci. USA; 103; pp. 10834-10839; (2006).
Humphreys et al; “Synthetic Peptide Vaccine Against Pandemic H5N1 Influenza Based on li-Key Modified MHC Class II Epitopes”; Pharmaceutical Discovery & Development; May/Jun. 2006; pp. 25, 26 and 29.
Iler, R. K.; “Multilayers of Colloidal Particles”; Journal of Colloid and Interface Science; 21; pp. 569-594; (1966).
Lvov, Y. et al; “Electrostatic Layer-by-Layer Assembly of Proteins and Polyions”; Protein Architecture: Interfacial Molecular Assembly and Immobilization Biotechnology; CRC Press; New York; 1528-1997; pp. 125-167; ISBN:0824782364; (1999).
Lvov, Y. et al; “Urease Encapsulation in Nanoorganized Microshells”; Nano Letters; 1; pp. 125-128; (2001).
Haynie, et al.; “Polypeptide Multilayer Films: Role of Molecular Structure and Charge”; Langmuir; 20; pp. 4540-4547; (2004).

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