Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1989-01-24
1991-06-11
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
530328, 530329, 530330, 514 16, 514 17, 514 18, C07K 706, C07K 730, A61K 3900, A61K 3724
Patent
active
050230778
ABSTRACT:
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
REFERENCES:
patent: 3931141 (1976-01-01), Wissmann et al.
patent: 4565805 (1986-01-01), Smirnov et al.
patent: 4687759 (1987-08-01), Martinez et al.
Kothary, P. et al., Biochem. Biophys. Res. Commun., 146(2): 884-888, 1987.
Nemeth, J. et al., Chem. Abs., 98:51653w, p. 495, 1982.
Dochray, G., Chem. Abs., 94:119200w, p. 506, 1980.
Yamaguchi, K. et al., Chem. Abs., 100:154661m, p. 373, 1983.
Dockray, "Regulatory Peptides", 1, 169-186 (1980).
Yanaihara et al., "Biomedical Research", 1, 242-247 (1980).
Yanaihara et al., "Gut Peptides", 26-33 (1979).
Sugano et al., The Journal of Biological Chemistry, vol. 260, No. 21, Sep. 25, 1985, pp. 11724-11729.
Jaffe et al., Gastroenterology, vol. 58, No. 2, Feb. 1970, pp. 151-156.
Jaffee et al., Surgery, vol. 69, No. 2, Feb. 1971, pp. 232-237.
Jaffe et al., Surgery, vol. 65, No. 4, Apr., 1969, pp. 633-639.
Hughes et al., Digestive Diseases, vol. 21, No. 3, Mar. 1976, pp. 201-204.
Wunsch et al., Z. Physiol. Chem., Jun. 1982, pp. 666-669.
Larsson, Neurohistochemoistry: Modern Methods and Applications, 1986, pp. 527-567.
Moroder et al., Gastrin and Cholecystokinin, Chemistry, Physiology and Pharmacology, 1987, pp. 21-32.
Dockray et al., Gastroenterology, vol. 68, No. 2, Feb. 1975, pp. 222-230.
Azuma et al., Gastroenterologia Japonica, vol. 21, No. 4, Aug. 1986, pp. 319-324.
Iwanaga et al., Biomedical Research, 1, 1980, pp. 316-320.
Varndell et al., Experientia, 39, 1983, pp. 713-717.
Larsson et al., The Journal of Histochemistry and Cytochemistry, vol. 25, No. 12, 1977, pp. 1317-1321.
Rehfeld et al., Scand. J. Clin. Lab. Invest., 30, 1972, pp. 221-232.
De Magistris et al., Analytical Biochemistry, 102, 1980, pp. 126-133.
Rehfeld et al., Regulatory Peptides, 2, 1981, pp. 333-342.
Gevas Philip C.
Grimes Stephen
Karr, Jr. Stephen L.
Littenberg Richard L.
Aphton Corporation
Perkins Susan
Schain Howard E.
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