Immunogenic compositions and methods for the treatment and preve

Details Immunogenic compositions and methods for the treatment and preve Immunogenic compositions and methods for the treatment and preve

1994-03-30

1997-04-22

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

530324, 530309, 530325, 530326, 530327, 530328, 530329, 530330, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 42419711, C07K 500, A61K 3900, A61K 3938, A61K 3800

Patent

active

056227027

ABSTRACT:
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.

REFERENCES:
patent: 3931141 (1976-01-01), Wissman et al.
patent: 4201770 (1980-05-01), Stevens
patent: 4384995 (1983-05-01), Stevens
patent: 4526716 (1985-07-01), Stevens
patent: 4565805 (1986-01-01), Smirnov et al.
patent: 4687759 (1987-08-01), Martinez et al.
patent: 4691006 (1987-09-01), Stevens
patent: 5023077 (1991-06-01), Gevas et al.
Larsson et al. Characterization of Antral Gastrin Cells with Region-Spicific . . . 1977. J. Histochem & Cytochem. 25(12):1317-21.
Kothary et al 1987. NH.sub.2 -terminal of Gastrin-17 in duodenal ulcer disease . . . BBRC. 146(2):884-888.
Dockray et al. 1975. Amino terminal Gastrin fragment in Secum . . . Gastroenterology 68(2):222-230.
Azuma et al. Immumocyto Chemical evidence for differential . . . Gastroenteralogia Japonica 21(4):319-24.
Nemeth et al. 1982. Development of a sequence-specific radioemmunoussay . . . Izotoptechnika 25(4):288-94.
Sugano et al., The Journal of Biological Chemistry, vol. 260, No. 21, Sep. 25, 1985, pp. 11724-11729.
Jaffe et al., Gastroenterology, vol. 58, No. 2, Feb. 1970, pp. 151-156.
Jaffe et al., Surgery, vol. 69, No. 2, Feb. 1971, pp. 232-237.
Jaffe et al., Surgery, vol. 65, No. 4, Apr. 1969, pp. 633-639.
Hughes et al., Digestive Diseases, vol. 21, No. 3, Mar. 1976, pp. 201-204.
Larsson, Neurohistochemoistry: Modern Methods and Applications, 1986, pp. 527-567.
Moroder et al., Gastrin and Cholecystokinin, Chemistry, Physiology and Pharmacology, 1987, pp. 21-32.
Dockray et al., Gastroenterology, vol. 68, No. 2, Feb. 1975, pp. 222-230.
Choudhury et al., Z. Physiol. Chem., Nov. 1980, pp. 1719-1733.
Azuma et al. Gastroenterologia Japonica, vol. 21, No. 4, Aug. 1986, pp. 319-324.
Varndell et al., Experientia, 39, 1983, pp. 713-717.
Rehfeld et al. Scand. J. Clin. Lab. Invest., 30, 1972, pp. 221-232.
De Magistris et al., Analytical Biochemistry, 102, 1980, pp. 126-133.
Rehfeld et al., Regulatory Peptides, 2, 1981, pp. 333-342.
Yamaguchi, K., et al., Chem. Abs., 100: 154661m, pp. 373, (1983).
Dockray, "Regulatory Peptides", 1, 169-186 (1980).
Nemeth et al. Chem. Abs. 98: 51653W. pp. 495, 1982.
Dockray, G. Chem. Abs. 94: 119200W. pp. 506, 1980.
Yanaihara et al., "Biomedical Research", 1, 242-247 (1980).
Yanaihara et al., "Gut Peptides", 26-33 (1979).
Kothary, et al., Biochem. Biophys. Res. Com. 146:186-188, 1987.
Larsson, "Characterization of Antral Gastrin Cells with Region-Specific Antiserum", J. Histochem. Cytocem. 25:1317-21, 1977.
Iwanaga, T. "Immunocytochenical Localization of the Different Gastrin Forms in the Pyloric Antrum:, " Biom. Res. 1:316-320, 1980.
Nemeth et al. "A Gastrin Aminoterminalis 1-13 Fragmensevel Kidolgozott, . . . ", Izotoptechnika 25: 288-294, 1982.
Beauchamp et al., Ann. Surg., 202, Sep. 1985, pp. 303-309.
Dockray, "Amino-terminal gastrin fragment in serum of Sollinger-Ellison Syndrome patients", Gatroenterology 68:222-230, 1975.
Lamote et al., Regulatory Peptides, 20, 1988, pp. 1-9.
Lamers et al., Eur. J. Cancer Clin. Oncol., vol. 24., No. 2, 1988, pp. 267-273.
Watson et al., in vitro, Br. J. Surg., vol. 75, Apr. 1988, pp. 342-345.
Kusyk et al., Am. J. Physiol., 251, 1986, pp. G597-G601.
Weinstock et al., Cancer Research, 48, Feb. 15, 1988, pp. 932-937.
Smith et al., Gastroenterology, 95 1988, pp. 1541-1548.
Rae-Venter et al., Gastroenterology, vol. 80, No. 5, 1986, p. 1256.

Affiliated with

Also associated with

Rating

Immunogenic compositions and methods for the treatment and preve does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunogenic compositions and methods for the treatment and preve, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunogenic compositions and methods for the treatment and preve will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-339797