Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1991-01-25
1993-10-26
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Lymphokine
424 88, 424 89, 424 90, 424 91, 424 92, 424 943, 530363, 530405, 530409, 530395, 530807, 436546, 525 541, A61K 39395, A61K 39385, C07K 1706
Patent
active
052564096
ABSTRACT:
An immunogenic composition for raising antisera to a drug comprising immunologically active carrier protein to which is bound at least two types of hapten, each hapten comprising a drug molecule and, optionally, a bridging group, a method of raising antisera to a drug using said immunogenic composition, and a method of alleviating an overdose of a tricyclic depressant drug comprising an effective amount of antisera raised to an immunogen.
REFERENCES:
patent: 4235864 (1980-11-01), Kaul et al.
patent: 4495281 (1985-01-01), Buckler et al.
patent: 4620977 (1986-11-01), Strahilevitz
patent: 4629691 (1986-12-01), Collins et al.
patent: 4780312 (1988-10-01), Talwar
O'Callaghan et al., (1987) J. Neurochemistry 49 C4):109/-5.
Chu et al. (1982) J. Immunol. Methods 55:73-78.
Erlanger (1980) Methods Enzymol. 70:85-104.
Liu et al., (1987) Clin. toxicol. 25(7):527-538.
Dart et al. (1991) Vet. Hum. Toxicol. 33(4) Abstr. #31.
Brunn et al., (1991) Int. J. Immunopharmac. 13(7) 841-851.
K. P. Maguire et al., "A Radioimmunoassay For Nortriptyline (And Other Tricyclic Antidepressants) In Plasma", Clinical Chemistry, 24(4): 549-554 (1978).
G. W. Aherne, et al., "The Radioimmunoassay of Tricyclic Antidepressants", British Journal of Clinical Pharmacology, 3:561-565 (1976).
G. P. Mould et al., "Radioimmunoassay of Amitriptyline and Nortriptyline In Body Fluids", Annals of Clinical Biochemistry, 15:221-225 (1978).
G. W. Aherne et al., "Radioimmunoassay For Nortriptyline and Amitriptyliner", The Lancet, p. 1214 (Jun. 4, 1977).
J. D. Robinson, et al., "Measurement of Plasma Nortriptyline Concentrations: Radioimmunoassay and Gas-Chromatography Compared", Clinical Chemistry, 24(11):2023-2025 (1978).
J. D. Robinson et al., "A Radioimmunoassay For The Determination of Combined Amitriptyline and Nortriptyline Concentrations In Microliter Samples of Plasma", The Journal of Pharmacology and Experimental Therapeutics, 205(2):499-502 (1978).
K. Robinson et al., "Radioimmunoassay of Tricyclic Antidepressant and Some Phenothiazine Drugs In Forensic Toxicology", Journal of Immunoassay, 6(1&2):11-22 (1985).
S. Spector et al., "Radioimmunoassay For Desmethylimipramine", Psycho-Pharmacology Communications, 1(4):421-429 (1975).
B. Kaul et al., "Screening For Tricyclic Antidepressant Drugs In Biological Specimens By Radioimmunoassay", Journal of Analytical Toxicology, 1:236-243 (Sept./Oct. 1977).
R. Lucek et al., "Specific Radioimmunoassay For Amitriptyline and Nortriptyline In Plasma", Research Communications in Chemical Pathology and Pharmacology, 18(1):125-136 (Sep. 1977).
J. W. Hubbard et al., "Radioimmunoassay For Psychotropic Drugs II: Synthesis and Properties Of Haptens For Tricyclic Antidepressants", Journal of Pharmaceutical Sciences, 67(11):1571-1578 (Nov. 1978).
K. K. Midha et al., "Monitoring Of Therapeutic Concentrations of Psychotropic Drugs In Plasma By Radioimmunoassays", Journal of Analytical Toxicology, 2:185-192 (Sep./Oct. 1978).
G. F. Read et al., "A Specific Radio-immunoassay Procedure For Plasma Clomipramine", Postgraduate Medical Journal, 53(4):110-116 (1977).
G. F. Read et al., "Determination of A Tricyclic Antidepressant, Clomipramine (Anafranil), In Plasma By A Specific Radioimmunoassay, Procedure", Clinical Chemistry, 24(1):36-40 (1978).
D. J. Brunswick et al., "Radioimmunoassay of Imipramine and Desmethyl-imipramine", Life Sciences, 22(2):137-146 (1978).
D. J. Brunswick et al., "Specific Radioimmunoassay of Amitriptyline And Nortriptyline", British Journal of Clinical Pharmacology, 7:343-348 (1979).
P. A. Mason et al., "Development and Evaluation Of A Radioimmunoassay For The Analysis Of Body Fluids To Determine The Presence Of Tricyclic Anti-depressant Drugs", Analyst. 109:1213-1215 (Sep. 1984).
R. S. Kamel et al., "Novel 125I-Labeled Nortriptyline Derivatives And Their Use In Liquid-Phase Or Magnetizable Solid-Phase Second-Antibody Radioimmunoassays", Clinical Chemistry, 25(12):1997-2002 (1979).
R. Virtanen, "Radioimmunoassay For Tricyclic Antidepressants", The Scandinavian Journal of Clinical & Laboratory Investigation, 40:191-197 (1980).
H. Denis et al., "Enzyme-Linked Immunosorbent Assay For Amitriptyline and Other Antidepressants Using A Monoclonal Antibody", Clinica Chimica Acta, 159:257-267 (1986).
M. N. Al-Bassam et al., "Double-Antibody Enzyme Immunoassay For Nortriptyline", Clinical Chemistry, 24(9):1590-1594 (1978).
R. C. Dorey, "Results Compared For Tricyclic Antidepressants As Assayed By Liquid Chromatography And Enzyme Immunoassay", Clinical Chemistry, 34(11):2348-2351 (1988).
B. A. Scoggins et al., "Measurement of Tricyclic Antidepressants, Part I, A Review of Methodology", Clinical Chemistry, 26(1):5-17 (1980).
B. A. Scoggins et al., "Measurement Of Tricyclic Antidepressants, Part II, Applications Of Methodology", Clinical Chemistry, 26(7):805-815 (1980).
P. Pentel et al., "Redistribution Into Plasma Of Tracer Doses Of Desipramine by Anti-desipramine Antiserum In Rats", Biochemical Pharmacology, 36(2):293-295 (1987).
A. Sabouraud et al., "The Effect Of Nortriptyline-specific Active Immunization On Amitriptyline Toxicity And Disposition In The Rabbit", Toxicology, 62:349-360 (1990).
M. J. Hursting et al., "Tricyclic Antidepressant-Specific Fab Fragments Alter The Distribution and Elimination Of Desipramine In The Rabbit: A Model For Overdose Treatment", Clinical Toxicology, 27(1&2):53-66 (1989).
P. R. Pentel et al., "Redistribution Of Tricyclic Antidepressants In Rats Using A Drug-Specific Monoclonal Antibody: Dose-Response Relationship", Drug Metabolism and Disposition, 19(1)24-28 (1991).
P. R. Pental et al., "Pretreatment With Drug-Specific Antibody Reduces Desipramine Cardiotoxicity In Rats", Life Sciences, 48(7):675-683 (1991).
A. Sabouraud et al., "Immunotherapy Of Tricyclic Antidepressant Poisoning: Recent Experimental Data", Lyons Poison Center's 30th Anniversary and EAPCCT Technical Meeting (May 22-24, 1991).
A. J. Heath, "Immunotherapy For Tricyclic Antidepressant Poisoning: A Clinical Perspective", Lyons Poison Center's 30th Anniversary and EAPCCT Technical Meeting (May 22-24, 1991).
Kim Kay K.
Nucker Christine M.
Therapeutic Antibodies Inc.
LandOfFree
Immunogenic composition against tricyclic antidepressant drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunogenic composition against tricyclic antidepressant drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunogenic composition against tricyclic antidepressant drugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-957517