Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-05-22
1998-01-20
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
435 693, 4351721, 530300, 530350, 536 2372, A61K 3912, C12N 1500, C07K 100, C07H 2102
Patent
active
057098654
ABSTRACT:
This invention relates to the identification of Bovine Viral Diarrhea Virus group II (BVDV-II) nucleic acid sequences (e.g., gp53 sequences), to methods of using the nucleic acid sequences for detecting BVD-II virus in animal sera, to polypeptide vital antigens derived from the sequences and immunoreactive with sera from animals infected with Bovine Viral Diarrhea group II (BVD-II) virus, to polynucleotide sequences which encode these polypeptide antigens, to an expression system capable of producing the polypeptide antigens, to vaccines containing the polypeptide antigens, to methods of using the polypeptide antigens for detecting BVD-II virus antibodies in animal sera, and to antibodies directed against these polypeptide antigens.
REFERENCES:
patent: 5206163 (1993-04-01), Renard et al.
Becher, P., et al., "Molecular Characterization of Border Disease Virus, a Pestivirus from Sheep," Virology 198:542-551 (1994).
Paton, D.J., et al., "Epitope Mapping of the gp53 Envelope Protein of Bovine Viral Diarrhea Virus," Virology 190:763-772 (1992).
Paton, D.J., et al., "Stability of the gp53 Gene of a Bovine Viral Diarrhoea Virus Isolated at Different Times from a Persistently Infected Steer," Br. Vet. J. 150:603-607 (1994).
Pellerin, C., et al., "Identification of a New Group of Bovine Viral Diarrhea Virus Strains Associated with Severe Outbreaks and High Mortalities," Virology 203:260-268 (1994).
Ridpath, J.F., et al., "Segregation of bovine Viral Diarrhea Virus into Genotypes," Virology 205:66-74 (1994).
Sullivan, D.G., and Akkina, R., "Protein and Genomic Analysis of Border Disease Virus," Abstract, presented at IXth Int'l Congress of Virology, Glasgow, Scotland, Aug. 8-13 (1993).
Sullivan, D.G., et al., "Structural Gene Analysis of Border Disease Virus," Abstract, presented at 74th Conf. of Research Workers in Animal Diseases, Fort Collins, Colorado, USA, Nov. 8-9 (1993).
Sullivan, D.G., et al., "Nucleotide Sequence Analysis of the Structural Gene Coding Region of the Pestivirus Border Disease Virus," Virus Research 33:219-228 (1994).
Tijssen Peter
van den Hurk Jan
Biostar Inc.
Knode Marian C.
Salimi Ali R.
Sholtz Charles K.
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